PDF(Pubmed)
Abstract：
Mold infestations in buildings pose significant challenges to human health, affecting both private residences and hospitals. While molds commonly trigger asthma and allergies in the immunocompetent, they can cause life-threatening diseases in the immunocompromised. Currently, there is an unmet need for new strategies to reduce or prevent mold infestations. Far-UVC technology can inactivate microorganisms while remaining safe for humans. This study investigates the inhibitory efficacy of far-UVC light at 222 nm on the growth of common mold-producing fungi, specifically Penicillium candidum, when delivered in low-dose on-off duty cycles, a configuration consistent with its use in real-world settings. The inhibitory effect of the low-dose duty cycles was assessed on growth induced by i) an adjacent spore-producing P. candidum donor and ii) P. candidum spores seeded directly onto agar plates. In both setups, the far-UVC light significantly inhibited both vertical and horizontal growth of P. candidum, even when the UV doses were below the Threshold Value Limit of 23 mJ/cm2. These results suggest that far-UVC light holds the potential to improve indoor air quality by reducing or preventing mold growth, also when people are present.
摘要：
建筑物中的霉菌侵扰对人类健康构成重大挑战，影响私人住宅和医院。虽然霉菌通常会引发免疫能力强的哮喘和过敏，它们会在免疫功能低下的人中引起危及生命的疾病。目前,对减少或预防霉菌感染的新策略的需求尚未得到满足。远UVC技术可以灭活微生物，同时对人类保持安全。这项研究调查了222nm远UVC光对常见霉菌真菌生长的抑制作用，特别是白青霉，当以低剂量开-关占空比输送时，与在现实世界设置中的使用一致的配置。评估了低剂量工作循环对以下因素诱导的生长的抑制作用：i）相邻的产孢子的念珠菌供体和ii）直接接种到琼脂板上的念珠菌孢子。在这两种设置中，远UVC光显着抑制念珠菌的垂直和水平生长，即使紫外线剂量低于23mJ/cm2的阈值极限。这些结果表明，远紫外线灯具有通过减少或防止霉菌生长来改善室内空气质量的潜力，当人们在场的时候。
