PDF(Pubmed)
Abstract：
Developing T1-weighted magnetic resonance imaging (MRI) contrast agents with enhanced biocompatibility and targeting capabilities is crucial owing to concerns over current agents\' potential toxicity and suboptimal performance. Drawing inspiration from \"biomimetic camouflage,\" we isolated cell membranes (CMs) from human glioblastoma (T98G) cell lines via the extrusion method to facilitate homotypic glioma targeting. At an 8:1 mass ratio of ferric chloride hexahydrate to gallic acid (GA), the resulting iron (Fe)-GA nanoparticles (NPs) proved effective as a T1-weighted MRI contrast agent. T98G CM-coated Fe-GA NPs demonstrated improved homotypic glioma targeting, validated through Prussian blue staining and in vitro MRI. This biomimetic camouflage strategy holds promise for the development of targeted theranostic agents in a safe and effective manner.
摘要：
开发具有增强的生物相容性和靶向能力的T1加权磁共振成像（MRI）造影剂至关重要，因为人们担心当前药物的潜在毒性和次优性能。从“仿生伪装”中汲取灵感，“我们通过挤压方法从人胶质母细胞瘤（T98G）细胞系中分离细胞膜（CMs），以促进同源型胶质瘤的靶向。在六水合氯化铁与没食子酸(GA)的质量比为8:1时，所得的铁（Fe）-GA纳米颗粒（NPs）被证明是有效的T1加权MRI造影剂。T98GCM涂层的Fe-GANP显示出改善的同型胶质瘤靶向，通过普鲁士蓝染色和体外MRI验证。这种仿生伪装策略有望以安全有效的方式开发靶向治疗药物。
