Abstract：
BACKGROUND: All skin tones need to be protected from the damaging effects of solar radiation. Although mineral sunscreens offer protection, they can have a thick, greasy feel and leave a white cast, particularly on darker skin tones. Tints offset white cast and provide visible light protection; however, patients may prefer a sheer option. Therefore, a multifunctional, sheer, 100% mineral sunscreen moisturizer (MSM) with broad-spectrum SPF 50 was developed to have positive aesthetics and deliver anti-aging and skin health benefits to all skin tones. Methods: An IRB-approved, 12-week, open-label clinical study was conducted to investigate the efficacy and tolerability of the MSM. Thirty-nine (39) females aged 35 to 60 years with moderate-severe overall facial photodamage and representing all Fitzpatrick skin types (FST) were recruited. Participants applied the MSM to the face and neck in the morning and reapplied per US Food and Drug Administration requirements. Efficacy and tolerability grading, photography, ultrasound imaging, corneometer measurements, and questionnaires were completed at baseline and weeks 4, 8, and 12. Results: Statistically significant progressive improvements were demonstrated from baseline to week 12. At week 12, 23.4% and 26.5% mean improvements in overall photodamage were seen for FST I-III and FST IV-VI, respectively. Favorable tolerability was shown for both the face and neck. Photography corroborated clinical grading, and ultrasound imaging indicated a trend in skin density improvement. The MSM was well-perceived. Conclusion: The MSM is an efficacious and well-tolerated product for patients of all skin tones who desire a sheer, 100% mineral sunscreen moisturizer with anti-aging and skin health benefits. J Drugs Dermatol. 2024;23(7):538-544. doi:10.36849/JDD.8082.
摘要：
背景：需要保护所有肤色免受太阳辐射的破坏性影响。虽然矿物防晒霜提供保护，他们可以有一个厚厚的，油腻的感觉，留下一个白色的石膏，特别是在较暗的肤色上。Tintsoffsetwhitecastandprovidevisiblelightprotection;however,患者可能更喜欢纯粹的选择。因此,一个多功能的，纯粹，具有广谱SPF50的100％矿物防晒保湿剂（MSM）的开发具有积极的美学效果，并为所有肤色提供抗衰老和皮肤健康益处。方法:经IRB批准的,12周,我们进行了开放标签临床研究,以研究MSM的疗效和耐受性.招募了39（39）名年龄在35至60岁之间的女性，这些女性具有中度至重度的整体面部光损伤，代表了所有Fitzpatrick皮肤类型（FST）。参与者在早上将MSM应用于面部和颈部，并根据美国食品和药物管理局的要求重新应用。疗效和耐受性分级，摄影,超声成像,角膜测量仪测量，问卷在基线和第4,8和12周完成.结果：从基线到第12周，有统计学意义的渐进性改善。在第12周，FSTI-III和FSTIV-VI的总体光损伤平均改善了23.4％和26.5％，分别。面部和颈部均显示出良好的耐受性。摄影证实了临床分级，和超声成像显示皮肤密度改善的趋势。MSM被很好地感知。结论：MSM是一种有效且耐受性良好的产品，适用于所有希望获得纯粹肤色的患者，100%矿物防晒保湿霜，具有抗衰老和皮肤健康益处。J药物Dermatol。2024；23（7）：538–544。doi:10.36849/JDD.8082。
