Abstract：
BACKGROUND: Limited epidemiologic data has suggested direct associations between hair pigment, race, and incidence of alopecia areata (AA). Here, we examine the relationship between natural hair color, race, and the lifetime risk alopecia.
METHODS: In this case-control study, we included UK Biobank patients of all races and self-reported hair color with diagnoses of AA, androgenetic alopecia (AGA), or scarring alopecia (SA). Multivariable logistic regression was used to detect differences in lifetime risk.
RESULTS: Findings reveal a significantly increased risk of AA among individuals with black hair compared to dark brown hair (OR 1.71 [95% CI 1.22-2.38], p < 0.001). Those with red or blonde hair showed a decreased risk of AA (0.74 [0.56-0.97]; 0.62 [0.41-0.95], p < 0.05). No racial differences in AA prevalence were observed among individuals with black hair.
CONCLUSIONS: Darker hair colors may be associated with a higher risk of AA, lighter hair colors with a lower risk, and differences in hair color could contribute to previously noted racial variations in AA incidence, potentially influencing dermatologists\' perspectives on the disease\'s epidemiology.
METHODS: In this case-control study, we included UK Biobank patients of all races and self-reported hair color with diagnoses of AA, androgenetic alopecia (AGA), or scarring alopecia (SA). Multivariable logistic regression was used to detect differences in lifetime risk.
RESULTS: Findings reveal a significantly increased risk of AA among individuals with black hair compared to dark brown hair (OR 1.71 [95% CI 1.22-2.38], p < 0.001). Those with red or blonde hair showed a decreased risk of AA (0.74 [0.56-0.97]; 0.62 [0.41-0.95], p < 0.05). No racial differences in AA prevalence were observed among individuals with black hair.
CONCLUSIONS: Darker hair colors may be associated with a higher risk of AA, lighter hair colors with a lower risk, and differences in hair color could contribute to previously noted racial variations in AA incidence, potentially influencing dermatologists\' perspectives on the disease\'s epidemiology.
摘要：
背景：有限的流行病学数据表明，头发色素，种族,斑秃（AA）的发病率。这里,我们研究自然发色之间的关系，种族,和终生脱发的风险。
方法：在本病例对照研究中，我们包括所有种族的UKBiobank患者和自我报告的头发颜色，诊断为AA，雄激素性脱发（AGA），或瘢痕性脱发（SA）。多变量逻辑回归用于检测终生风险的差异。
结果：研究结果表明，与深棕色头发相比，黑头发的个体患AA的风险显着增加（OR1.71[95％CI1.22-2.38]，p<0.001)。红发或金发者患AA的风险降低（0.74[0.56-0.97];0.62[0.41-0.95]，p<0.05)。在黑发个体中没有观察到AA患病率的种族差异。
结论：较深的头发颜色可能与较高的AA风险有关，头发颜色较浅，风险较低，头发颜色的差异可能导致先前注意到的AA发病率的种族差异，潜在影响皮肤科医生对疾病流行病学的看法。
方法：在本病例对照研究中，我们包括所有种族的UKBiobank患者和自我报告的头发颜色，诊断为AA，雄激素性脱发（AGA），或瘢痕性脱发（SA）。多变量逻辑回归用于检测终生风险的差异。
结果：研究结果表明，与深棕色头发相比，黑头发的个体患AA的风险显着增加（OR1.71[95％CI1.22-2.38]，p<0.001)。红发或金发者患AA的风险降低（0.74[0.56-0.97];0.62[0.41-0.95]，p<0.05)。在黑发个体中没有观察到AA患病率的种族差异。
结论：较深的头发颜色可能与较高的AA风险有关，头发颜色较浅，风险较低，头发颜色的差异可能导致先前注意到的AA发病率的种族差异，潜在影响皮肤科医生对疾病流行病学的看法。
