Abstract：
OBJECTIVE: Chronic migraine is a disabling progressive disorder without effective management approaches. Animal models have been developed and used in chronic migraine research. However, there are several problems with existing models. Therefore, we aimed to summarize and analyze existing animal models to facilitate translation from basic to clinical.
RESULTS: The most commonly used models are the inflammatory soup induction model and the nitric oxide donor induction model. In addition, KATP openers have also been used in model induction. Based on the above models, some molecular targets have been identified, such as glutamate receptors. However, each model has its shortcomings and characteristics, and there are still some common problems that need to be solved, such as spontaneous headache, evaluation criteria after model establishment, and identification methods. In this review, we summarized and highlighted the advantages and limitations of the currently commonly used animal models of chronic migraine with a special focus on drug discovery and current therapeutic strategies, and discussed the directions that can be worked on in the future.
RESULTS: The most commonly used models are the inflammatory soup induction model and the nitric oxide donor induction model. In addition, KATP openers have also been used in model induction. Based on the above models, some molecular targets have been identified, such as glutamate receptors. However, each model has its shortcomings and characteristics, and there are still some common problems that need to be solved, such as spontaneous headache, evaluation criteria after model establishment, and identification methods. In this review, we summarized and highlighted the advantages and limitations of the currently commonly used animal models of chronic migraine with a special focus on drug discovery and current therapeutic strategies, and discussed the directions that can be worked on in the future.
摘要：
目的：慢性偏头痛是一种无有效治疗方法的致残性进行性疾病。已经开发了动物模型并将其用于慢性偏头痛研究。然而,现有模型存在几个问题。因此,我们旨在总结和分析现有的动物模型，以促进从基础到临床的转化。
结果：最常用的模型是炎症汤诱导模型和一氧化氮供体诱导模型。此外,KATP开放剂也已用于模型诱导。基于上述模型，已经确定了一些分子靶标，如谷氨酸受体。然而,每种模型都有其缺点和特点，还有一些共同的问题需要解决，比如自发性头痛，模型建立后的评价标准，和识别方法。在这次审查中,我们总结并强调了目前常用的慢性偏头痛动物模型的优点和局限性，特别关注药物发现和当前的治疗策略。并讨论了未来可以发展的方向。
结果：最常用的模型是炎症汤诱导模型和一氧化氮供体诱导模型。此外,KATP开放剂也已用于模型诱导。基于上述模型，已经确定了一些分子靶标，如谷氨酸受体。然而,每种模型都有其缺点和特点，还有一些共同的问题需要解决，比如自发性头痛，模型建立后的评价标准，和识别方法。在这次审查中,我们总结并强调了目前常用的慢性偏头痛动物模型的优点和局限性，特别关注药物发现和当前的治疗策略。并讨论了未来可以发展的方向。
