Abstract：
The studies regarding prevalence, outcomes, and predictors of prolonged corrected QT (QTc) among COVID-19 patients not on QTc-prolonging medication are not available in the literature. In this retrospective cohort study, the QTc of 295 hospital-admitted COVID-19 patients was analyzed and its association with in-hospital mortality was determined. The QTc was prolonged in 14.6% (43/295) of the study population. Prolonged QTc was seen in patients with older age (P = 0.018), coronary artery disease (P = 0.001), congestive heart failure (P = 0.042), elevated N-terminal-pro-B-type natriuretic peptide (NT-ProBNP) (P < 0.0001), and on remdesivir (P = 0.046). No episode of torsades de pointes arrhythmia or any arrhythmic death was observed among patients with prolonged QTc. The mortality was significantly high in patients with prolonged QTc (P = 0.003). The multivariate logistic regression analysis showed coronary artery disease (odds ratio (OR): 4.153, 95% CI 1.37-14.86; P = 0.013), and NT-ProBNP (ng/L) (OR: 1.000, 95% CI 1.000-1.000; P = 0.007) as predictors of prolonged QTc. The prolonged QTc was associated with the worst in-hospital survival (p by log-rank 0.001). A significant independent association was observed between prolonged QTc and in-hospital mortality in multivariate cox-regression analysis (adjusted hazard ratio: 3.861; (95% CI 1.719-6.523), P < 0.0001). QTc was found to be a marker of underlying comorbidities among COVID-19 patients. Prolonged QTc in hospitalized COVID-19 patients was independently associated with in-hospital mortality.
摘要：
关于患病率的研究，结果，文献中没有未使用QTc延长药物的COVID-19患者的校正QT（QTc）延长的预测因素。在这项回顾性队列研究中，对295例住院COVID-19患者的QTc进行分析,并确定其与院内死亡率的相关性.14.6%(43/295)的研究人群QTc延长。老年患者QTc延长(P=0.018),冠状动脉疾病（P=0.001），充血性心力衰竭（P=0.042），N末端B型利钠肽前体（NT-ProBNP）升高（P<0.0001），和remdesivir（P=0.046）。在QTc延长的患者中，未观察到尖端扭转性心律失常或任何心律失常死亡。QTc延长患者的死亡率明显较高（P=0.003）。多因素logistic回归分析显示冠心病(比值比(OR):4.153,95%CI1.37-14.86;P=0.013),和NT-ProBNP（ng/L）（OR：1.000，95％CI1.000-1.000；P=0.007）作为QTc延长的预测因子。QTc延长与最差的住院生存率相关(p=log-rank=0.001)。在多变量cox回归分析中观察到QTc延长与住院死亡率之间存在显著的独立关联(调整后的风险比:3.861;(95%CI1.719-6.523),P<0.0001)。QTc被发现是COVID-19患者潜在合并症的标志。住院COVID-19患者QTc延长与住院死亡率独立相关。
