Abstract：
This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement.
摘要：
这项研究检查了产前大麻暴露与自闭症谱系障碍（ASD）诊断和特征之间的关联。来自美国国立卫生研究院资助的对儿童健康结果的环境影响联盟的34个队列中的11,570名儿童（1-18岁；53％的男性；25％的西班牙裔；60％的白人）的样本被纳入分析。广义线性混合模型的结果复制了先前的研究，表明在控制相关协变量时，产前大麻暴露与儿童ASD特征之间的关联并不显著。特别是烟草暴露。儿童生物性别并未减轻产前大麻暴露与ASD之间的关联。在大样本中，连续测量ASD性状，没有证据表明产前接触大麻会增加ASD的风险.这项工作有助于通过解决对统计能力和ASD测量的担忧来澄清以前的混合发现。
