Abstract：
Dendritic cells (DCs) are specialized antigen-presenting cells for lymphocytes, including regulatory T (Treg) cells, a subset of CD4+ T cells expressing CD25 and Foxp3, a transcription factor. Treg cells maintain immunological self-tolerance in mice and humans, and suppress autoimmunity and other various immune responses such as tumor immunity, transplant rejection, allergy, responses to microbes, and inflammation. Treg cell proliferation is controlled by antigen-presenting DCs. On the other hand, Treg cells suppress the function of DCs by restraining DC maturation. Therefore, the interaction between DCs and Treg cells, DC-Treg crosstalk, could contribute to controlling health and disease. We recently found that unique DC-Treg crosstalk plays a role in several conditions. First, Treg cells are expanded in ultraviolet-B (UVB)-exposed skin by interacting with DCs, and the UVB-expanded Treg cells have a healing function. Second, manipulating DC-Treg crosstalk can induce effective acquired immune responses against SARS-CoV2 antigens without adjuvants. Third, Treg cells with a special feature interact with DCs in the tumor microenvironment of human head and neck squamous cell cancer, which may contribute to the prognosis. Understanding the underlying mechanisms of DC-Treg crosstalk may provide a novel strategy to control health and disease.
摘要：
树突状细胞（DC）是淋巴细胞的专门抗原呈递细胞，包括调节性T（Treg）细胞，表达CD25和转录因子Foxp3的CD4+T细胞亚群。Treg细胞在小鼠和人类中保持免疫自我耐受性，并抑制自身免疫和其他各种免疫反应，如肿瘤免疫，移植排斥,过敏,对微生物的反应，和炎症。Treg细胞增殖受抗原呈递DC控制。另一方面,Treg细胞通过抑制DC成熟来抑制DC的功能。因此,DC和Treg细胞之间的相互作用，DC-Treg串扰，可能有助于控制健康和疾病。我们最近发现，独特的DC-Treg串扰在几种情况下起作用。首先,Treg细胞通过与DC相互作用在紫外线B（UVB）暴露的皮肤中扩增，UVB扩增的Treg细胞具有愈合功能。第二,操纵DC-Treg串扰可以在没有佐剂的情况下诱导针对SARS-CoV2抗原的有效获得性免疫应答。第三，在人头颈部鳞状细胞癌的肿瘤微环境中，具有特殊特征的Treg细胞与DC相互作用，这可能有助于预后。了解DC-Treg串扰的潜在机制可能提供控制健康和疾病的新策略。
