Abstract：
UNASSIGNED: There hasn\'t been research done on the connection between serum anion gap (AG) levels and long-, medium-, and short-term all-cause mortality in congestive heart failure (CHF) patients. This study aims to investigate the association between serum anion gap levels and all-cause mortality in CHF patients after adjusting for other covariates.
UNASSIGNED: For each patient, we gather demographic information, comorbidities, laboratory results, vital signs, and scoring data using the ICU (Intensive Care Unit) Admission Scoring System from the MIMIC-III database. The connection between baseline AG and long-, medium-, and short-term all-cause mortality in critically ill congestive heart failure patients was investigated using Kaplan-Meier survival curves, subgroup analysis, restricted cubic spline, and Cox proportional risk analysis.
UNASSIGNED: 4840 patients with congestive heart failure in total were included in this study. With a mean age of 72.5 years, these patients had a gender split of 2567 males and 2273 females. After adjusting for other covariates, a multiple regression analysis revealed that, in critically ill patients with congestive heart failure, all-cause mortality increased significantly with rising AG levels. In the fully adjusted model, we discovered that AG levels were strongly correlated with 4-year, 365-day, 90-day, and 30-day all-cause mortality in congestive heart failure patients with HRs (95% CI) of 1.06 (1.04, 1.08); 1.08 (1.05, 1.10); and 1.08 (1.05, 1.11) (p-value < 0.05). Our subgroup analysis\'s findings demonstrated a high level of consistency and reliability. K-M survival curves demonstrate that high serum AG levels are associated with a lower survival probability.
UNASSIGNED: Our research showed the association between CHF patients\' all-cause mortality and anion gap levels was non-linear. Elevated anion gap levels are associated with an increased risk of long-, medium-, and short-term all-cause death in patients with congestive heart failure. Continuous monitoring of changes in AG levels may have a clinical predictive role.
UNASSIGNED: For each patient, we gather demographic information, comorbidities, laboratory results, vital signs, and scoring data using the ICU (Intensive Care Unit) Admission Scoring System from the MIMIC-III database. The connection between baseline AG and long-, medium-, and short-term all-cause mortality in critically ill congestive heart failure patients was investigated using Kaplan-Meier survival curves, subgroup analysis, restricted cubic spline, and Cox proportional risk analysis.
UNASSIGNED: 4840 patients with congestive heart failure in total were included in this study. With a mean age of 72.5 years, these patients had a gender split of 2567 males and 2273 females. After adjusting for other covariates, a multiple regression analysis revealed that, in critically ill patients with congestive heart failure, all-cause mortality increased significantly with rising AG levels. In the fully adjusted model, we discovered that AG levels were strongly correlated with 4-year, 365-day, 90-day, and 30-day all-cause mortality in congestive heart failure patients with HRs (95% CI) of 1.06 (1.04, 1.08); 1.08 (1.05, 1.10); and 1.08 (1.05, 1.11) (p-value < 0.05). Our subgroup analysis\'s findings demonstrated a high level of consistency and reliability. K-M survival curves demonstrate that high serum AG levels are associated with a lower survival probability.
UNASSIGNED: Our research showed the association between CHF patients\' all-cause mortality and anion gap levels was non-linear. Elevated anion gap levels are associated with an increased risk of long-, medium-, and short-term all-cause death in patients with congestive heart failure. Continuous monitoring of changes in AG levels may have a clinical predictive role.
摘要：
■尚未对血清阴离子间隙（AG）水平与长-之间的联系进行研究，medium-,充血性心力衰竭（CHF）患者的短期全因死亡率。本研究旨在探讨调整其他协变量后CHF患者血清阴离子间隙水平与全因死亡率之间的关系。
■对于每位患者，我们收集人口统计信息，合并症,实验室结果,生命体征,和使用来自MIMIC-III数据库的ICU（重症监护病房）入院评分系统的评分数据。基线AG和long-之间的连接，medium-,使用Kaplan-Meier生存曲线研究了危重充血性心力衰竭患者的短期全因死亡率，亚组分析，受限三次样条,和Cox比例风险分析。
■本研究共纳入了4840例充血性心力衰竭患者。平均年龄为72.5岁,这些患者的性别差异为2567名男性和2273名女性.在调整其他协变量后，多元回归分析显示,在患有充血性心力衰竭的危重患者中，全因死亡率随着AG水平的升高而显著增加.在完全调整的模型中，我们发现AG水平与4年密切相关，365天,90天,充血性心力衰竭患者的30天全因死亡率(95%CI)为1.06(1.04,1.08);1.08(1.05,1.10);1.08(1.05,1.11)(p值<0.05)。我们的亚组分析结果证明了高度的一致性和可靠性。K-M存活曲线表明高血清AG水平与较低的存活概率相关。
■我们的研究表明，CHF患者的全因死亡率和阴离子间隙水平之间的关联是非线性的。阴离子间隙水平升高与长期风险增加相关，medium-,充血性心力衰竭患者的短期全因死亡。连续监测AG水平的变化可能具有临床预测作用。
■对于每位患者，我们收集人口统计信息，合并症,实验室结果,生命体征,和使用来自MIMIC-III数据库的ICU（重症监护病房）入院评分系统的评分数据。基线AG和long-之间的连接，medium-,使用Kaplan-Meier生存曲线研究了危重充血性心力衰竭患者的短期全因死亡率，亚组分析，受限三次样条,和Cox比例风险分析。
■本研究共纳入了4840例充血性心力衰竭患者。平均年龄为72.5岁,这些患者的性别差异为2567名男性和2273名女性.在调整其他协变量后，多元回归分析显示,在患有充血性心力衰竭的危重患者中，全因死亡率随着AG水平的升高而显著增加.在完全调整的模型中，我们发现AG水平与4年密切相关，365天,90天,充血性心力衰竭患者的30天全因死亡率(95%CI)为1.06(1.04,1.08);1.08(1.05,1.10);1.08(1.05,1.11)(p值<0.05)。我们的亚组分析结果证明了高度的一致性和可靠性。K-M存活曲线表明高血清AG水平与较低的存活概率相关。
■我们的研究表明，CHF患者的全因死亡率和阴离子间隙水平之间的关联是非线性的。阴离子间隙水平升高与长期风险增加相关，medium-,充血性心力衰竭患者的短期全因死亡。连续监测AG水平的变化可能具有临床预测作用。
