Abstract：
BACKGROUND: Organs at risk (OAR) dose reporting for total body irradiation (TBI) patients is limited, and standardly reported only as mean doses to the lungs and kidneys. Consequently, dose received and effects on other OAR remain unexplored. To remedy this gap, this study reports dose data on an extensive list of OAR for patients treated at a single institution using the modulated arc total body irradiation (MATBI) technique.
METHODS: An audit was undertaken of all patients treated with MATBI between January 2015 and March 2021 who had completed their course of treatment. OAR were contoured on MATBI patient treatment plans, with 12 Gy in six fraction prescription. OAR dose statistics and dose volume histogram data are reported for the whole body, lungs, kidneys, bones, brain, lens, heart, liver and bowel bag.
RESULTS: The OAR dose data for 29 patients are reported. Mean dose results are body 11.77 Gy, lungs 9.86 Gy, kidneys 11.84 Gy, bones 12.03 Gy, brain 12.12 Gy, right lens 12.31 Gy, left lens 12.64 Gy, heart 11.07 Gy, liver 11.81 Gy and bowel bag 12.06 Gy. Dose statistics at 1-Gy intervals of V6-V13 for lungs and V10-V13 for kidneys are also included.
CONCLUSIONS: This is the first time an extensive list of OAR data has been reported for any TBI technique. Due to the paucity of reporting, this information could be used by centres implementing the MATBI technique, in addition to aiding comparison between TBI techniques, with the potential for greater understanding of the relationship between dose volume data and toxicity.
METHODS: An audit was undertaken of all patients treated with MATBI between January 2015 and March 2021 who had completed their course of treatment. OAR were contoured on MATBI patient treatment plans, with 12 Gy in six fraction prescription. OAR dose statistics and dose volume histogram data are reported for the whole body, lungs, kidneys, bones, brain, lens, heart, liver and bowel bag.
RESULTS: The OAR dose data for 29 patients are reported. Mean dose results are body 11.77 Gy, lungs 9.86 Gy, kidneys 11.84 Gy, bones 12.03 Gy, brain 12.12 Gy, right lens 12.31 Gy, left lens 12.64 Gy, heart 11.07 Gy, liver 11.81 Gy and bowel bag 12.06 Gy. Dose statistics at 1-Gy intervals of V6-V13 for lungs and V10-V13 for kidneys are also included.
CONCLUSIONS: This is the first time an extensive list of OAR data has been reported for any TBI technique. Due to the paucity of reporting, this information could be used by centres implementing the MATBI technique, in addition to aiding comparison between TBI techniques, with the potential for greater understanding of the relationship between dose volume data and toxicity.
摘要：
背景：全身照射（TBI）患者的危险器官（OAR）剂量报告有限，标准报告仅作为肺和肾脏的平均剂量。因此,收到的剂量和对其他OAR的影响仍未探索。为了弥补这个差距，本研究报告了使用调制电弧全身照射(MATBI)技术在单一机构接受治疗的患者的广泛OAR列表中的剂量数据.
方法：对2015年1月至2021年3月期间接受MATBI治疗的所有患者进行了审核，这些患者已经完成了治疗过程。在MATBI患者治疗计划上绘制了OAR轮廓，六分处方中的12Gy。报告全身的OAR剂量统计和剂量体积直方图数据，肺,肾脏，骨头,大脑,镜头,心,肝脏和肠袋。
结果：报告了29名患者的OAR剂量数据。平均剂量结果为身体11.77Gy，肺9.86Gy，肾脏11.84Gy，骨头12.03Gy，大脑12.12Gy，右镜头12.31Gy,左镜头12.64Gy,心脏11.07Gy，肝脏11.81Gy和肠袋12.06Gy。还包括用于肺的V6-V13和用于肾的V10-V13的1-Gy间隔的剂量统计。
结论：这是首次报道任何TBI技术的OAR数据的广泛列表。由于缺乏报道，这些信息可以由实施MATBI技术的中心使用，除了帮助比较TBI技术之外，有可能更好地了解剂量体积数据和毒性之间的关系。
方法：对2015年1月至2021年3月期间接受MATBI治疗的所有患者进行了审核，这些患者已经完成了治疗过程。在MATBI患者治疗计划上绘制了OAR轮廓，六分处方中的12Gy。报告全身的OAR剂量统计和剂量体积直方图数据，肺,肾脏，骨头,大脑,镜头,心,肝脏和肠袋。
结果：报告了29名患者的OAR剂量数据。平均剂量结果为身体11.77Gy，肺9.86Gy，肾脏11.84Gy，骨头12.03Gy，大脑12.12Gy，右镜头12.31Gy,左镜头12.64Gy,心脏11.07Gy，肝脏11.81Gy和肠袋12.06Gy。还包括用于肺的V6-V13和用于肾的V10-V13的1-Gy间隔的剂量统计。
结论：这是首次报道任何TBI技术的OAR数据的广泛列表。由于缺乏报道，这些信息可以由实施MATBI技术的中心使用，除了帮助比较TBI技术之外，有可能更好地了解剂量体积数据和毒性之间的关系。
