PDF(Pubmed)
Abstract：
Evolutionary biology provides a unifying theory for testing hypotheses about the relationship between hormones and person perception. Person perception usually receives attention from the perspective of sexual selection. However, because person perception is one trait in a suite regulated by hormones, univariate approaches are insufficient. In this Perspectives article, quantitative genetics is presented as an important but underutilized framework for testing evolutionary hypotheses within this literature. We note tacit assumptions within the current literature on psychiatric genetics, which imperil the interpretation of findings thus far. As regulators of a diverse manifold of traits, hormones mediate tradeoffs among an array of functions. Hormonal pleiotropy also provides the basis of correlational selection, a process whereby selection on one trait in a hormone-mediated suite generates selection on the others. This architecture provides the basis for conflicts between sexual and natural selection within hormone-mediated suites. Due to its role in person perception, psychiatric disorders, and reproductive physiology, the sex hormone estrogen is highlighted as an exemplar here. The implications of this framework for the evolution of person perception are discussed. Empirical quantification of selection on traits within hormone-mediated suites remains an important gap in this literature with great potential to illuminate the fundamental nature of psychiatric disorders.
摘要：
进化生物学为测试有关激素与人的感知之间关系的假设提供了统一的理论。人的感知通常从性选择的角度受到关注。然而,因为人的感知是由激素调节的套房中的一个特征，单变量方法是不够的。在这篇观点文章中，定量遗传学被认为是检验本文献中进化假设的一个重要但未得到充分利用的框架。我们注意到目前关于精神病学遗传学的文献中的默契假设，这危及到目前为止对发现的解释。作为多种特征的调节器，激素介导一系列功能之间的权衡。激素多效性也提供了相关选择的基础，在激素介导的套件中对一种性状的选择产生对其他性状的选择的过程。这种结构为激素介导的套件中的性选择和自然选择之间的冲突提供了基础。由于它在人的感知中的作用，精神疾病,和生殖生理学，这里强调性激素雌激素是一个例子。讨论了该框架对人的感知演变的影响。激素介导的套件中性状选择的经验量化仍然是该文献中的重要空白，具有阐明精神疾病基本性质的巨大潜力。
