PDF(Pubmed)
Abstract：
This study delves into functional brain-heart interplay (BHI) dynamics during interictal periods before and after seizure events in focal epilepsy. Our analysis focuses on elucidating the causal interaction between cortical and autonomic nervous system (ANS) oscillations, employing electroencephalography and heart rate variability series. The dataset for this investigation comprises 47 seizure events from 14 independent subjects, obtained from the publicly available Siena Dataset. Our findings reveal an impaired brain-heart axis especially in the heart-to-brain functional direction. This is particularly evident in bottom-up oscillations originating from sympathovagal activity during the transition between preictal and postictal periods. These results indicate a pivotal role of the ANS in epilepsy dynamics. Notably, the brain-to-heart information flow targeting cardiac oscillations in the low-frequency band does not display significant changes. However, there are noteworthy changes in cortical oscillations, primarily originating in central regions, influencing heartbeat oscillations in the high-frequency band. Our study conceptualizes seizures as a state of hyperexcitability and a network disease affecting both cortical and peripheral neural dynamics. Our results pave the way for a deeper understanding of BHI in epilepsy, which holds promise for the development of advanced diagnostic and therapeutic approaches also based on bodily neural activity for individuals living with epilepsy.
This study focuses on brain-heart interplay (BHI) during pre- and postictal periods surrounding seizures. Employing multichannel EEG and heart rate variability data from subjects with focal epilepsy, our analysis reveals a disrupted brain-heart axis dynamic, particularly in the heart-to-brain direction. Notably, sympathovagal activity alterations during preictal to postictal transitions underscore the autonomic nervous system’s pivotal role in epilepsy dynamics. While brain-to-heart information flow targeting low-frequency band cardiac oscillations remains stable, significant changes occur in cortical oscillations, predominantly in central regions, influencing high-frequeny-band heartbeat oscillations, that is, vagal activity. Viewing seizures as states of hyperexcitability and confirming focal epilepsy as a network disease affecting both central and peripheral neural dynamics, our study enhances understanding of BHI in epilepsy. These findings offer potential for advanced diagnostic and therapeutic approaches grounded in bodily neural activity for individuals with epilepsy.
This study focuses on brain-heart interplay (BHI) during pre- and postictal periods surrounding seizures. Employing multichannel EEG and heart rate variability data from subjects with focal epilepsy, our analysis reveals a disrupted brain-heart axis dynamic, particularly in the heart-to-brain direction. Notably, sympathovagal activity alterations during preictal to postictal transitions underscore the autonomic nervous system’s pivotal role in epilepsy dynamics. While brain-to-heart information flow targeting low-frequency band cardiac oscillations remains stable, significant changes occur in cortical oscillations, predominantly in central regions, influencing high-frequeny-band heartbeat oscillations, that is, vagal activity. Viewing seizures as states of hyperexcitability and confirming focal epilepsy as a network disease affecting both central and peripheral neural dynamics, our study enhances understanding of BHI in epilepsy. These findings offer potential for advanced diagnostic and therapeutic approaches grounded in bodily neural activity for individuals with epilepsy.
摘要：
这项研究探讨了局灶性癫痫发作前后发作间期的功能性脑-心脏相互作用（BHI）动力学。我们的分析重点是阐明皮层和自主神经系统（ANS）振荡之间的因果相互作用，采用脑电图和心率变异性系列。这项调查的数据集包括来自14名独立受试者的47例癫痫发作事件，从公开可用的锡耶纳数据集获得。我们的发现揭示了大脑-心脏轴受损，尤其是在心脏-大脑功能方向上。在发作前和发作后的过渡期间，由交感迷走神经活动引起的自下而上的振荡尤其明显。这些结果表明ANS在癫痫动力学中的关键作用。值得注意的是,针对低频段心脏振荡的脑-心信息流未显示显著变化.然而,皮层振荡有值得注意的变化，主要起源于中部地区，影响高频带的心跳振荡。我们的研究将癫痫发作概念化为过度兴奋状态和影响皮质和周围神经动力学的网络疾病。我们的研究结果为更深入地了解癫痫中的BHI铺平了道路，这有望为癫痫患者开发基于身体神经活动的先进诊断和治疗方法。
这项研究的重点是在癫痫发作前后的脑心相互作用（BHI）。使用来自局灶性癫痫患者的多通道EEG和心率变异性数据，我们的分析揭示了大脑-心脏轴的动态中断，特别是从心到脑的方向.值得注意的是,发作前到发作后过渡期间的交感神经活动改变强调了自主神经系统在癫痫动力学中的关键作用。虽然针对低频带心脏振荡的脑-心信息流保持稳定，皮层振荡发生显著变化，主要在中部地区，影响高频带心跳振荡，也就是说,迷走神经活动。将癫痫发作视为过度兴奋状态，并确认局灶性癫痫是一种影响中枢神经和周围神经动力学的网络疾病，我们的研究提高了对癫痫患者BHI的认识.这些发现为癫痫患者的身体神经活动提供了先进的诊断和治疗方法的潜力。
这项研究的重点是在癫痫发作前后的脑心相互作用（BHI）。使用来自局灶性癫痫患者的多通道EEG和心率变异性数据，我们的分析揭示了大脑-心脏轴的动态中断，特别是从心到脑的方向.值得注意的是,发作前到发作后过渡期间的交感神经活动改变强调了自主神经系统在癫痫动力学中的关键作用。虽然针对低频带心脏振荡的脑-心信息流保持稳定，皮层振荡发生显著变化，主要在中部地区，影响高频带心跳振荡，也就是说,迷走神经活动。将癫痫发作视为过度兴奋状态，并确认局灶性癫痫是一种影响中枢神经和周围神经动力学的网络疾病，我们的研究提高了对癫痫患者BHI的认识.这些发现为癫痫患者的身体神经活动提供了先进的诊断和治疗方法的潜力。
