PDF(Pubmed)
Abstract：
Our study rationale was to establish contemporary epidemiological data on malaria and schistosomiasis among school-going children in Chikwawa District before future environmental changes associated with the Shire Valley Transformation Programme occurred. Our cross-sectional surveys tested 1134 children from 21 government-owned primary schools (approximately 50 children per school); rapid diagnostic tests for malaria (Humasis Pf/PAN) and intestinal schistosomiasis (urine-Circulating Cathodic Antigen) were used, with urine reagents strips and egg-filtration with microscopy for urogenital schistosomiasis. All infected children were treated with an appropriate dose of Lonart® (for malaria) and/or Cesol® (for schistosomiasis). Across 21 schools the overall prevalence was 9.7% (95% CI: 8.8-10.6%) for malaria, 1.9% (95% CI: 1.4-2.3%) for intestinal schistosomiasis, and 35.0% (95% CI: 33.6-36.5%) for egg-patent urogenital schistosomiasis. The prevalence of co-infection of malaria with urogenital schistosomiasis was 5.5% (95% CI: 4.8-6.2%). In a third of the schools, the prevalence of malaria and urogenital schistosomiasis was above national averages of 10.5% and 40-50%, respectively, with two schools having maxima of 36.8% and 84.5%, respectively. Set against a background of ongoing control, our study has revealed an alarming burden of malaria and schistosomiasis in southern Malawi. These findings call for an immediate mitigating response that significantly bolsters current control interventions to better safeguard children\'s future health.
摘要：
我们的研究理由是在与ShireValley转型计划相关的未来环境变化发生之前，在Chikwawa区的学龄儿童中建立有关疟疾和血吸虫病的当代流行病学数据。我们的横断面调查测试了来自21所公立小学的1134名儿童（每所学校约50名儿童）；使用了疟疾（HumasisPf/PAN）和肠道血吸虫病（尿液循环阴极抗原）的快速诊断测试，用尿液试剂条和卵子过滤用显微镜检查泌尿生殖道血吸虫病。所有受感染的儿童均接受适当剂量的Lonart®（用于疟疾）和/或Cesol®（用于血吸虫病）治疗。在21所学校中，疟疾的总体患病率为9.7％（95％CI：8.8-10.6％），1.9%（95%CI：1.4-2.3%）为肠道血吸虫病，和35.0%（95%CI：33.6-36.5%）为卵未闭的泌尿生殖道血吸虫病。疟疾合并泌尿生殖道血吸虫病的患病率为5.5％（95％CI：4.8-6.2％）。在三分之一的学校里，疟疾和泌尿生殖道血吸虫病的患病率高于全国平均水平的10.5%和40-50%，分别,两所学校的最高比率分别为36.8%和84.5%，分别。在持续控制的背景下，我们的研究揭示了马拉维南部疟疾和血吸虫病的惊人负担。这些发现要求立即采取缓解措施，显着支持当前的控制干预措施，以更好地保护儿童的未来健康。
