PDF(Pubmed)
Abstract：
UNASSIGNED: Electronic healthcare records (EHRs) are used to document diagnoses, symptoms, tests, and prescriptions. Though not primarily collected for research purposes, owing to the size of the data as well as the depth of information collected, they have been used extensively to conduct epidemiological research. The Clinical Practice Research Datalink (CPRD) is an EHR database containing representative data of the UK population with regard to age, sex, race, and social deprivation measures. Fibrotic conditions are characterised by excessive scarring, contributing towards organ dysfunction and eventual organ failure. Fibrosis is associated with ageing as well as many other factors, it is hypothesised that fibrotic conditions are caused by the same underlying pathological mechanism. We calculated the prevalence of fibrotic conditions (as defined in a previous Delphi survey of clinicians) as well as the prevalence of fibrotic multimorbidity (the proportion of people with multiple fibrotic conditions).
UNASSIGNED: We included a random sample of 993,370 UK adults, alive, and enrolled at a UK general practice, providing data to the CPRD Aurum database as of 1st of January 2015. Individuals had to be eligible for linkage to hospital episode statistics (HES) and ONS death registration. We calculated the point prevalence of fibrotic conditions and multi-morbid fibrosis on the 1st of January 2015. Using death records of those who died in 2015, we investigated the prevalence of fibrosis associated death. We explored the most commonly co-occurring fibrotic conditions and determined the settings in which diagnoses were commonly made (primary care, secondary care or after death).
UNASSIGNED: The point prevalence of any fibrotic condition was 21.46%. In total, 6.00% of people had fibrotic multimorbidity. Of the people who died in 2015, 34.82% had a recording of a fibrotic condition listed on their death certificate.
UNASSIGNED: The key finding was that fibrotic multimorbidity affects approximately 1 in 16 people.
Fibrotic conditions are scarring conditions which impact the way an organ functions and eventually lead to organ failure. We studied routinely collected health data from GPs, hospitals, and death certificates to estimate the percentage of UK adults who had fibrotic diseases. We found that 1 in 5 people had at least one fibrotic disease, and we also found that 1 in 16 people had more than one fibrotic disease.
UNASSIGNED: We included a random sample of 993,370 UK adults, alive, and enrolled at a UK general practice, providing data to the CPRD Aurum database as of 1st of January 2015. Individuals had to be eligible for linkage to hospital episode statistics (HES) and ONS death registration. We calculated the point prevalence of fibrotic conditions and multi-morbid fibrosis on the 1st of January 2015. Using death records of those who died in 2015, we investigated the prevalence of fibrosis associated death. We explored the most commonly co-occurring fibrotic conditions and determined the settings in which diagnoses were commonly made (primary care, secondary care or after death).
UNASSIGNED: The point prevalence of any fibrotic condition was 21.46%. In total, 6.00% of people had fibrotic multimorbidity. Of the people who died in 2015, 34.82% had a recording of a fibrotic condition listed on their death certificate.
UNASSIGNED: The key finding was that fibrotic multimorbidity affects approximately 1 in 16 people.
Fibrotic conditions are scarring conditions which impact the way an organ functions and eventually lead to organ failure. We studied routinely collected health data from GPs, hospitals, and death certificates to estimate the percentage of UK adults who had fibrotic diseases. We found that 1 in 5 people had at least one fibrotic disease, and we also found that 1 in 16 people had more than one fibrotic disease.
摘要：
■电子医疗记录（EHR）用于记录诊断，症状,测试,和处方。虽然主要不是为了研究目的而收集的，由于数据的大小以及收集的信息的深度，它们已被广泛用于进行流行病学研究。临床实践研究数据链（CPRD）是一个EHR数据库，包含英国人口关于年龄的代表性数据，性别,种族,社会剥夺措施。纤维化条件的特征是过度的疤痕，导致器官功能障碍和最终的器官衰竭。纤维化与衰老以及许多其他因素有关，据推测，纤维化病症是由相同的潜在病理机制引起的。我们计算了纤维化疾病的患病率（如先前Delphi对临床医生的调查所定义的）以及纤维化多患病率（患有多种纤维化疾病的人的比例）。
■我们随机抽取了993,370名英国成年人，活着,并在英国的普通诊所注册，向CPRDAurum数据库提供数据，截至2015年1月1日。个人必须有资格与医院发作统计数据（HES）和ONS死亡登记挂钩。我们计算了2015年1月1日纤维化和多病态纤维化的点患病率。使用2015年死亡的死亡记录，我们调查了纤维化相关死亡的患病率。我们探索了最常见的并发纤维化疾病，并确定了通常进行诊断的设置（初级保健，二级保健或死后)。
■任何纤维化病症的点患病率为21.46%。总的来说,6.00％的人患有纤维化多发病。在2015年死亡的人中，34.82％的人在死亡证明上列出了纤维化疾病的记录。
■关键发现是纤维化多发病影响约16人中的1人。
纤维化状况是影响器官功能并最终导致器官衰竭的瘢痕形成状况。我们研究了常规从全科医生收集的健康数据，医院,和死亡证明，以估计英国成年人患有纤维化疾病的百分比。我们发现五分之一的人至少有一种纤维化疾病，我们还发现，每16人中就有1人患有一种以上的纤维化疾病。
■我们随机抽取了993,370名英国成年人，活着,并在英国的普通诊所注册，向CPRDAurum数据库提供数据，截至2015年1月1日。个人必须有资格与医院发作统计数据（HES）和ONS死亡登记挂钩。我们计算了2015年1月1日纤维化和多病态纤维化的点患病率。使用2015年死亡的死亡记录，我们调查了纤维化相关死亡的患病率。我们探索了最常见的并发纤维化疾病，并确定了通常进行诊断的设置（初级保健，二级保健或死后)。
■任何纤维化病症的点患病率为21.46%。总的来说,6.00％的人患有纤维化多发病。在2015年死亡的人中，34.82％的人在死亡证明上列出了纤维化疾病的记录。
■关键发现是纤维化多发病影响约16人中的1人。
纤维化状况是影响器官功能并最终导致器官衰竭的瘢痕形成状况。我们研究了常规从全科医生收集的健康数据，医院,和死亡证明，以估计英国成年人患有纤维化疾病的百分比。我们发现五分之一的人至少有一种纤维化疾病，我们还发现，每16人中就有1人患有一种以上的纤维化疾病。
