PDF(Pubmed)
Abstract：
This case report is of herpes zoster which is caused by Varicella zoster virus (VZV). The patient was presented with acute renal failure associated with intravenous acyclovir administration for its management. A 50 years old man visited the hospital with rashes on his back. The serum sample was positive for anti-VZV IgM via Enzyme Linked Immunosorbent Assay (ELISA), and vesicular swab for VZV via polymerase chain reaction (PCR). Phylogenetic analysis identified it as M2-genotype. Patient was treated with intravenous acyclovir administration, which led to acute renal failure. Later with shift to oral acyclovir, renal functions were restored. Elderly patients with reactivation of VZV in Pakistan are at risk to contract herpes zoster. Acyclovir is drug of choice via intravenous route was found to be nephrotoxic, however oral acyclovir was safe and effective. This is first report on pathogenic VZV genotype from Pakistan and is presented to highlight that the herpes zoster cases of elderly patients\' treatment option need to be revisited.
摘要：
该病例报告是由水痘带状疱疹病毒（VZV）引起的带状疱疹。该患者出现与静脉给药阿昔洛韦治疗相关的急性肾功能衰竭。一名50岁的男子到医院就诊，背部有皮疹。通过酶联免疫吸附试验（ELISA），血清样品的抗VZVIgM阳性，并通过聚合酶链反应（PCR）检测VZV的囊泡拭子。系统发育分析将其鉴定为M2基因型。患者静脉注射阿昔洛韦，导致急性肾衰竭.后来转向口服阿昔洛韦，肾功能恢复。巴基斯坦VZV再激活的老年患者有感染带状疱疹的风险。阿昔洛韦是通过静脉途径选择的药物，被发现具有肾毒性，然而口服阿昔洛韦安全有效.这是巴基斯坦首次报道致病性VZV基因型，并强调需要重新审视老年患者带状疱疹病例的治疗选择。
