PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this review was to examine the association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality rates in patients with acute pulmonary embolism (PE).
UNASSIGNED: PubMed Central, Scopus, Web of Science, and Embase were searched for studies reporting the association between NLR and PLR with mortality up to March 17th 2023. Adjusted ratios were sourced from studies and combined to generate pooled outcomes as odds ratio (OR) in a random-effects model. Risk of bias was assessed using the Newcastle Ottawa Scale.
UNASSIGNED: Fifteen studies were included. Meta-analysis showed that NLR was a significant predictor of mortality in patients with PE (OR: 1.42 95% CI: 1.26, 1.61 I2=92%). Results were unchanged on sensitivity analysis and subgroup analysis based on study location, method of diagnosis, sample size, overall mortality rates, cut-offs, and follow-up. Pooled analysis failed to demonstrate PLR as a predictor of mortality in patients with PE (OR: 1.00 95% CI: 1.00, 1.01 I2=57%). Results were unchanged on sensitivity analysis and subgroup analysis based on study location, diagnosis of PE, overall mortality rates, and cut-off.
UNASSIGNED: Current evidence from retrospective studies shows that NLR can independently predict mortality in acute PE. Data on PLR was limited and failed to indicate an independent role in the prognosis of PE patients. Registration No. PROSPERO (CRD42023407573).
UNASSIGNED: PubMed Central, Scopus, Web of Science, and Embase were searched for studies reporting the association between NLR and PLR with mortality up to March 17th 2023. Adjusted ratios were sourced from studies and combined to generate pooled outcomes as odds ratio (OR) in a random-effects model. Risk of bias was assessed using the Newcastle Ottawa Scale.
UNASSIGNED: Fifteen studies were included. Meta-analysis showed that NLR was a significant predictor of mortality in patients with PE (OR: 1.42 95% CI: 1.26, 1.61 I2=92%). Results were unchanged on sensitivity analysis and subgroup analysis based on study location, method of diagnosis, sample size, overall mortality rates, cut-offs, and follow-up. Pooled analysis failed to demonstrate PLR as a predictor of mortality in patients with PE (OR: 1.00 95% CI: 1.00, 1.01 I2=57%). Results were unchanged on sensitivity analysis and subgroup analysis based on study location, diagnosis of PE, overall mortality rates, and cut-off.
UNASSIGNED: Current evidence from retrospective studies shows that NLR can independently predict mortality in acute PE. Data on PLR was limited and failed to indicate an independent role in the prognosis of PE patients. Registration No. PROSPERO (CRD42023407573).
摘要：
■本综述的目的是研究急性肺栓塞（PE）患者中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）与死亡率之间的关系。
■PubMedCentral，Scopus,WebofScience,和Embase搜索了报告截至2023年3月17日NLR和PLR与死亡率之间关联的研究.调整后的比率来自研究，并在随机效应模型中组合以产生汇总结果作为比值比（OR）。使用纽卡斯尔渥太华量表评估偏倚风险。
■共纳入15项研究。Meta分析显示NLR是PE患者死亡率的显著预测因子(OR:1.4295%CI:1.26,1.61I2=92%)。基于研究地点的敏感性分析和亚组分析结果没有变化，诊断方法,样本量,总死亡率，截止日期,和后续行动。汇总分析未能证明PLR是PE患者死亡率的预测因子（OR：1.0095％CI：1.00，1.01I2=57％）。基于研究地点的敏感性分析和亚组分析结果没有变化，PE的诊断，总死亡率，和切断。
■目前来自回顾性研究的证据表明，NLR可以独立预测急性PE的死亡率。PLR的数据有限，未能表明在PE患者预后中的独立作用。登记号PROSPERO（CRD42023407573）。
■PubMedCentral，Scopus,WebofScience,和Embase搜索了报告截至2023年3月17日NLR和PLR与死亡率之间关联的研究.调整后的比率来自研究，并在随机效应模型中组合以产生汇总结果作为比值比（OR）。使用纽卡斯尔渥太华量表评估偏倚风险。
■共纳入15项研究。Meta分析显示NLR是PE患者死亡率的显著预测因子(OR:1.4295%CI:1.26,1.61I2=92%)。基于研究地点的敏感性分析和亚组分析结果没有变化，诊断方法,样本量,总死亡率，截止日期,和后续行动。汇总分析未能证明PLR是PE患者死亡率的预测因子（OR：1.0095％CI：1.00，1.01I2=57％）。基于研究地点的敏感性分析和亚组分析结果没有变化，PE的诊断，总死亡率，和切断。
■目前来自回顾性研究的证据表明，NLR可以独立预测急性PE的死亡率。PLR的数据有限，未能表明在PE患者预后中的独立作用。登记号PROSPERO（CRD42023407573）。
