PDF(Pubmed)
Abstract：
Contrast-enhanced ultrasonography (CEUS) has been established as a diagnostic tool for assessing microvascularization, essential for understanding angiogenesis in neoplastic development.
OBJECTIVE: This study assesses the effectiveness of CEUS as a supplementary tool to TIRADS in enhancing the ultrasound-based diagnosis of thyroid cancer.
METHODS: Over one year, 157 nodules in 133 patients, with predominantly solid thyroid nodules, were examined using ultrasound and CEUS and underwent thyroidectomy, allowing for a comparison of ultrasound findings with pathological reports.
RESULTS: Thyroid cancer was identified in 31.21% (49/157) of cases. Significant CEUS high-risk features included inhomogeneous enhancement, enhancement defects, and complete hypoenhancement (AUC 0.818, 0.767, 0.864 respectively). Nodules exhibiting any of these features were classified as high-risk in CEUS. The diagnostic performance of TIRADS improved when combined with CEUS, with AUC increasing from 0.707 to 0.840 and improved sensitivity.
CONCLUSIONS: The integration of CEUS with TIRADS significantly enhances the diagnostic accuracy and specificity in identifying thyroid cancer. This combination proves to be a more effective method for risk stratification and diagnosis, highlighting the value of CEUS as an adjunctive tool in thyroid cancer evaluation.
OBJECTIVE: This study assesses the effectiveness of CEUS as a supplementary tool to TIRADS in enhancing the ultrasound-based diagnosis of thyroid cancer.
METHODS: Over one year, 157 nodules in 133 patients, with predominantly solid thyroid nodules, were examined using ultrasound and CEUS and underwent thyroidectomy, allowing for a comparison of ultrasound findings with pathological reports.
RESULTS: Thyroid cancer was identified in 31.21% (49/157) of cases. Significant CEUS high-risk features included inhomogeneous enhancement, enhancement defects, and complete hypoenhancement (AUC 0.818, 0.767, 0.864 respectively). Nodules exhibiting any of these features were classified as high-risk in CEUS. The diagnostic performance of TIRADS improved when combined with CEUS, with AUC increasing from 0.707 to 0.840 and improved sensitivity.
CONCLUSIONS: The integration of CEUS with TIRADS significantly enhances the diagnostic accuracy and specificity in identifying thyroid cancer. This combination proves to be a more effective method for risk stratification and diagnosis, highlighting the value of CEUS as an adjunctive tool in thyroid cancer evaluation.
摘要：
超声造影（CEUS）已被确立为评估微血管形成的诊断工具，对于理解肿瘤发展中的血管生成至关重要。
目的：本研究评估了CEUS作为TIRADS的辅助工具在增强基于超声的甲状腺癌诊断中的有效性。
方法：一年以上，133例患者中有157个结节，以甲状腺实性结节为主，使用超声和CEUS检查，并接受甲状腺切除术，允许将超声检查结果与病理报告进行比较。
结果：在31.21%（49/157）的病例中发现了甲状腺癌。显著的CEUS高风险特征包括不均匀增强，增强缺陷，和完全增强（AUC分别为0.818、0.767、0.864）。表现出任何这些特征的结节在CEUS中被归类为高风险。与CEUS结合使用时，TIRADS的诊断性能得到改善，AUC从0.707增加到0.840，灵敏度提高。
结论：CEUS与TIRADS的结合显着提高了诊断甲状腺癌的准确性和特异性。这种组合被证明是一种更有效的风险分层和诊断方法，强调CEUS作为甲状腺癌评估辅助工具的价值。
目的：本研究评估了CEUS作为TIRADS的辅助工具在增强基于超声的甲状腺癌诊断中的有效性。
方法：一年以上，133例患者中有157个结节，以甲状腺实性结节为主，使用超声和CEUS检查，并接受甲状腺切除术，允许将超声检查结果与病理报告进行比较。
结果：在31.21%（49/157）的病例中发现了甲状腺癌。显著的CEUS高风险特征包括不均匀增强，增强缺陷，和完全增强（AUC分别为0.818、0.767、0.864）。表现出任何这些特征的结节在CEUS中被归类为高风险。与CEUS结合使用时，TIRADS的诊断性能得到改善，AUC从0.707增加到0.840，灵敏度提高。
结论：CEUS与TIRADS的结合显着提高了诊断甲状腺癌的准确性和特异性。这种组合被证明是一种更有效的风险分层和诊断方法，强调CEUS作为甲状腺癌评估辅助工具的价值。
