Abstract：
Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.
摘要：
抑制皮脂细胞中的脂质合成对于痤疮治疗是必需的。天然产物衍生物质对脂质合成的影响是未知的。这项研究研究了芒果叶水提取物（WEML）对人皮脂腺细胞脂质合成的影响。低血清条件下的Sebocyte分化增加了脂质积累和增殖物激活受体γ表达。WEML处理显著抑制皮脂腺细胞中的脂质积累和成脂mRNA表达。芒果苷,WEML中的一种生物活性化合物，还通过AKT途径减少脂质积累和成脂mRNA表达。因此，WEML和芒果苷有效抑制皮脂腺细胞的脂质合成，显示痤疮治疗的希望。
