Abstract：
The vascular endothelium dynamically responds to environmental cues and plays a pivotal role in maintaining vascular homeostasis by regulating vasomotor tone, blood cell trafficking, permeability and immune responses. However, endothelial dysfunction results in various pathological conditions. Inflammasomes are large intracellular multimeric complexes activated by pathogens or cellular damage. Inflammasomes in vascular endothelial cells (ECs) initiate innate immune responses, which have emerged as significant mediators in endothelial dysfunction, contributing to the pathophysiology of an array of diseases. This review summarizes the mechanisms and ramifications of inflammasomes in ECs and related vascular diseases such as atherosclerosis, abdominal aortic aneurysm, stroke, and lung and kidney diseases. We also discuss potential drugs targeting EC inflammasomes and their applications in treating vascular diseases.
摘要：
血管内皮动态响应环境信号，并通过调节血管舒缩张力在维持血管稳态中起关键作用。血细胞贩运，渗透性和免疫反应。然而,内皮功能障碍导致各种病理状况。炎性体是由病原体或细胞损伤激活的大的细胞内多聚体复合物。血管内皮细胞（ECs）中的炎性体启动先天免疫反应，它们已经成为内皮功能障碍的重要介质，有助于一系列疾病的病理生理学。本文综述了炎性小体在内皮细胞和动脉粥样硬化等相关血管疾病中的作用机制和影响。腹主动脉瘤,中风,以及肺部和肾脏疾病。我们还讨论了针对EC炎性体的潜在药物及其在治疗血管疾病中的应用。
