PDF(Pubmed)
Abstract：
OBJECTIVE: To identify recurrent venous thromboembolism (VTE) after discontinuation of anticoagulation in patients with isolated distal deep vein thrombosis based on its anatomic localization (axial or muscular veins).
METHODS: Data were sourced from PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases in the time period up to October 2023. The study followed PRISMA guidelines using a registered protocol (CRD42023443029). Studies reporting recurrent VTE in patients with axial or muscular DVT were included in the analysis.
RESULTS: Five studies with a total of 1,403 participants were evaluated. The results showed a pooled odds ratio of 1.12 (95% confidence interval 0.77-1.63) between axial and muscular DVT. Heterogeneity was low (I2 = 0%, p = 0.91) and there was no significant difference in the rate of recurrent VTE between axial and muscular DVT in each subgroup.
CONCLUSIONS: Muscular and axial DVT showed comparable recurrent VTE rates after anticoagulation. However, uncertainties regarding the possibility of recurrence affecting the popliteal vein or resulting in pulmonary embolism following muscular DVT anticoagulation persisted. Randomized trials in patients with isolated distal DVT are still needed to clarify its prognosis for different anatomical thrombus locations.
METHODS: Data were sourced from PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases in the time period up to October 2023. The study followed PRISMA guidelines using a registered protocol (CRD42023443029). Studies reporting recurrent VTE in patients with axial or muscular DVT were included in the analysis.
RESULTS: Five studies with a total of 1,403 participants were evaluated. The results showed a pooled odds ratio of 1.12 (95% confidence interval 0.77-1.63) between axial and muscular DVT. Heterogeneity was low (I2 = 0%, p = 0.91) and there was no significant difference in the rate of recurrent VTE between axial and muscular DVT in each subgroup.
CONCLUSIONS: Muscular and axial DVT showed comparable recurrent VTE rates after anticoagulation. However, uncertainties regarding the possibility of recurrence affecting the popliteal vein or resulting in pulmonary embolism following muscular DVT anticoagulation persisted. Randomized trials in patients with isolated distal DVT are still needed to clarify its prognosis for different anatomical thrombus locations.
摘要：
目的：根据解剖定位（轴系或肌系静脉）确定孤立性远端深静脉血栓形成患者抗凝停药后静脉血栓栓塞（VTE）复发。
方法：数据来自PubMed，Embase,科克伦图书馆,WebofScience,以及截至2023年10月的ClinicalTrials.gov数据库。该研究遵循PRISMA指南，使用注册方案（CRD42023443029）。报告轴性或肌性DVT患者VTE复发的研究包括在分析中。
结果：对共有1,403名参与者的5项研究进行了评估。结果显示，轴性和肌性DVT之间的合并比值比为1.12（95％置信区间0.77-1.63）。异质性低(I2=0%，p=0.91），每个亚组中轴性和肌性DVT之间的VTE复发率没有显着差异。
结论：抗凝治疗后，肌性和轴性DVT显示出相当的VTE复发率。然而,关于肌性DVT抗凝后影响the静脉复发或导致肺栓塞的可能性的不确定性仍然存在.仍需要在孤立的远端DVT患者中进行随机试验，以阐明其在不同解剖血栓位置的预后。
方法：数据来自PubMed，Embase,科克伦图书馆,WebofScience,以及截至2023年10月的ClinicalTrials.gov数据库。该研究遵循PRISMA指南，使用注册方案（CRD42023443029）。报告轴性或肌性DVT患者VTE复发的研究包括在分析中。
结果：对共有1,403名参与者的5项研究进行了评估。结果显示，轴性和肌性DVT之间的合并比值比为1.12（95％置信区间0.77-1.63）。异质性低(I2=0%，p=0.91），每个亚组中轴性和肌性DVT之间的VTE复发率没有显着差异。
结论：抗凝治疗后，肌性和轴性DVT显示出相当的VTE复发率。然而,关于肌性DVT抗凝后影响the静脉复发或导致肺栓塞的可能性的不确定性仍然存在.仍需要在孤立的远端DVT患者中进行随机试验，以阐明其在不同解剖血栓位置的预后。
