PDF(Pubmed)
Abstract：
Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME). Mesenchymal stromal cells (MSCs) play a pivotal role in cancer generation, progression, and immunosuppressive tumor microenvironment. Within the TME, MSCs encompass both resident and circulating counterparts that dynamically communicate and actively participate in TME immunosurveillance and response to ICB. This review aims to reevaluate various facets of MSCs, including their potential self-transformation to function as cancer-initiating cells and contributions to the creation of a conducive environment for tumor proliferation and metastasis. Additionally, we explore the immune regulatory functions of tumor-associated MSCs (TA-MSCs) and MSC-derived extracellular vesicles (MSC-EVs) with analysis of potential connections between circulating and tissue-resident MSCs. A comprehensive understanding of the dynamics of MSC-immune cell communication and the heterogeneous cargo of tumor-educated versus naïve MSCs may unveil a new MSC-mediated immunosuppressive pathway that can be targeted to enhance cancer control by ICB.
摘要：
免疫检查点阻断（ICB）需要彻底了解肿瘤微环境（TME）内复杂的细胞相互作用。间充质基质细胞(MSCs)在肿瘤的产生中起着举足轻重的作用,programming,和免疫抑制肿瘤微环境。在TME内部,MSC包括动态通信并积极参与TME免疫监视和对ICB的反应的居民和循环对应物。这篇综述旨在重新评估MSCs的各个方面，包括它们作为癌症启动细胞的潜在自我转化，以及对创造有利于肿瘤增殖和转移的环境的贡献。此外,我们探讨了肿瘤相关MSCs(TA-MSCs)和MSC来源的细胞外囊泡(MSC-EVs)的免疫调节功能,并分析了循环和组织驻留的MSCs之间的潜在联系.全面了解MSC-免疫细胞通讯的动力学以及受肿瘤教育的MSC与未经治疗的MSC的异质性货物可能会揭示一种新的MSC介导的免疫抑制途径，该途径可以通过ICB靶向增强癌症控制。
