PDF(Pubmed)
Abstract：
BACKGROUND: Merkel cell carcinoma (MCC) is a rare, aggressive, cutaneous tumour with high mortality and frequently delayed diagnosis. Clinically, it often manifests as a rapidly growing erythematous to purple nodule usually located on the lower extremities or face and scalp of elderly patients. There is limited available data on the dermoscopic findings of MCC, and there are no specific features that can be used to definitively diagnose MCC.
OBJECTIVE: Here, we aimed to summarize existing published literature on dermatoscopic and reflectance confocal microscopy (RCM) features of MCC.
METHODS: To find relevant studies, we searched the PubMed and Scopus databases from inception to April 12, 2023. Our goal was to identify all pertinent research that had been written in English. The following search strategy was employed: (\" dermoscopy\" OR \" dermatoscopy\" OR \" videodermoscopy\" OR \" videodermatoscopy\" OR \" reflectance confocal microscopy\") AND \" Merkel cell carcinoma\". Two dermatologists, DK and GE, evaluated the titles and abstracts separately for eligibility. For inclusion, only works written in English were taken into account.
RESULTS: In total 16 articles were retrieved (68 cases). The main dermoscopic findings of MCC are a polymorphous vascular pattern including linear irregular, arborizing, glomerular, and dotted vessels on a milky red background, with shiny or non-shiny white areas. Pigmentation was lacking in all cases. The RCM images showed a thin and disarranged epidermis, and small hypo-reflective cells that resembled lymphocytes arranged in solid aggregates outlined by fibrous tissue in the dermis. Additionally, there were larger polymorphic hyper-reflective cells that likely represented highly proliferative cells.
CONCLUSIONS: Dermoscopic findings of MCC may play a valuable role in evaluating MCC, aiding in the early detection and differentiation from other skin lesions. Further prospective case-control studies are needed to validate these results.
OBJECTIVE: Here, we aimed to summarize existing published literature on dermatoscopic and reflectance confocal microscopy (RCM) features of MCC.
METHODS: To find relevant studies, we searched the PubMed and Scopus databases from inception to April 12, 2023. Our goal was to identify all pertinent research that had been written in English. The following search strategy was employed: (\" dermoscopy\" OR \" dermatoscopy\" OR \" videodermoscopy\" OR \" videodermatoscopy\" OR \" reflectance confocal microscopy\") AND \" Merkel cell carcinoma\". Two dermatologists, DK and GE, evaluated the titles and abstracts separately for eligibility. For inclusion, only works written in English were taken into account.
RESULTS: In total 16 articles were retrieved (68 cases). The main dermoscopic findings of MCC are a polymorphous vascular pattern including linear irregular, arborizing, glomerular, and dotted vessels on a milky red background, with shiny or non-shiny white areas. Pigmentation was lacking in all cases. The RCM images showed a thin and disarranged epidermis, and small hypo-reflective cells that resembled lymphocytes arranged in solid aggregates outlined by fibrous tissue in the dermis. Additionally, there were larger polymorphic hyper-reflective cells that likely represented highly proliferative cells.
CONCLUSIONS: Dermoscopic findings of MCC may play a valuable role in evaluating MCC, aiding in the early detection and differentiation from other skin lesions. Further prospective case-control studies are needed to validate these results.
摘要：
背景：默克尔细胞癌（MCC）是一种罕见的，侵略性,皮肤肿瘤具有高死亡率和经常延迟诊断。临床上,它通常表现为快速生长的红斑至紫色结节，通常位于老年患者的下肢或面部和头皮。关于MCC的皮肤镜检查结果的可用数据有限，并且没有可用于明确诊断MCC的特定功能。
目标：这里，我们旨在总结现有发表的关于MCC的皮肤镜和反射共聚焦显微镜（RCM）特征的文献。
方法：为了找到相关研究，我们检索了从成立到2023年4月12日的PubMed和Scopus数据库.我们的目标是确定所有用英语写的相关研究。采用以下搜索策略：（“皮肤镜检查”或“皮肤镜检查”或“视频皮肤镜检查”或“视频皮肤镜检查”或“反射共聚焦显微镜”）和“默克尔细胞癌”。两位皮肤科医生,DK和GE,分别评估标题和摘要的资格。为了纳入，只考虑了用英语写的作品。
结果：共检索到16篇（68例）。MCC的主要皮肤镜检查结果是多形性血管模式，包括线性不规则，硼酸化,肾小球，和乳红色背景上点缀的血管，有光泽或无光泽的白色区域。在所有情况下都缺乏色素沉着。RCM图像显示表皮薄而混乱，和小的低反射细胞，类似淋巴细胞，排列在真皮纤维组织轮廓的固体聚集体中。此外,有较大的多态高反射细胞，可能代表高度增殖的细胞。
结论：MCC的皮肤镜检查结果可能在评估MCC中起重要作用，有助于早期发现和区分其他皮肤病变。需要进一步的前瞻性病例对照研究来验证这些结果。
目标：这里，我们旨在总结现有发表的关于MCC的皮肤镜和反射共聚焦显微镜（RCM）特征的文献。
方法：为了找到相关研究，我们检索了从成立到2023年4月12日的PubMed和Scopus数据库.我们的目标是确定所有用英语写的相关研究。采用以下搜索策略：（“皮肤镜检查”或“皮肤镜检查”或“视频皮肤镜检查”或“视频皮肤镜检查”或“反射共聚焦显微镜”）和“默克尔细胞癌”。两位皮肤科医生,DK和GE,分别评估标题和摘要的资格。为了纳入，只考虑了用英语写的作品。
结果：共检索到16篇（68例）。MCC的主要皮肤镜检查结果是多形性血管模式，包括线性不规则，硼酸化,肾小球，和乳红色背景上点缀的血管，有光泽或无光泽的白色区域。在所有情况下都缺乏色素沉着。RCM图像显示表皮薄而混乱，和小的低反射细胞，类似淋巴细胞，排列在真皮纤维组织轮廓的固体聚集体中。此外,有较大的多态高反射细胞，可能代表高度增殖的细胞。
结论：MCC的皮肤镜检查结果可能在评估MCC中起重要作用，有助于早期发现和区分其他皮肤病变。需要进一步的前瞻性病例对照研究来验证这些结果。
