PDF(Pubmed)
Abstract：
While light can affect emotional and cognitive processes of the medial prefrontal cortex (mPFC), no light-encoding was hitherto identified in this region. Here, extracellular recordings in awake mice revealed that over half of studied mPFC neurons showed photosensitivity, that was diminished by inhibition of intrinsically photosensitive retinal ganglion cells (ipRGCs), or of the upstream thalamic perihabenular nucleus (PHb). In 15% of mPFC photosensitive neurons, firing rate changed monotonically along light-intensity steps and gradients. These light-intensity-encoding neurons comprised four types, two enhancing and two suppressing their firing rate with increased light intensity. Similar types were identified in the PHb, where they exhibited shorter latency and increased sensitivity. Light suppressed prelimbic activity but boosted infralimbic activity, mirroring the regions\' contrasting roles in fear-conditioning, drug-seeking, and anxiety. We posit that prefrontal photosensitivity represents a substrate of light-susceptible, mPFC-mediated functions, which could be ultimately studied as a therapeutical target in psychiatric and addiction disorders.
摘要：
虽然光线可以影响内侧前额叶皮层（mPFC）的情绪和认知过程，迄今为止，在该区域尚未鉴定出光编码。这里,清醒小鼠的细胞外记录显示，超过一半的mPFC神经元显示出光敏性，通过抑制固有光敏视网膜神经节细胞（ipRGC）来减少，或丘脑上游的棘突周围核（PHb）。在15%的mPFC光敏神经元中，发射速率沿光强度步长和梯度单调变化。这些光强度编码神经元包括四种类型，两个增强和两个抑制他们的射击率与增加的光强度。在PHb中发现了类似的类型，它们表现出更短的潜伏期和更高的灵敏度。光抑制了前边缘活动，但增强了下边缘活动，反映区域在恐惧条件下的对比角色，寻求毒品,和焦虑。我们假设前额叶光敏性是一种光敏性的底物，mPFC介导的功能，最终可以作为精神病和成瘾疾病的治疗靶标进行研究。
