Abstract：
The morbidity of oral squamous cell carcinoma (OSCC) has been rising year after year, making it a major global health issue. But the molecular pathogenesis of OSCC is currently unclear. To study the potential pathogenesis of OSCC, the differentially expressed genes (DEGs) were screened, and multiple databases were used to perform the tumor stage, expression, prognosis, protein-protein interaction (PPI) networks, modules, and the functional enrichment analysis. Moreover, we have identified SP110 as the key candidate gene and conducted various analyses on it using multiple databases. The research indicated that there were 211 common DEGs, and they were enriched in various GO terms and pathways. Meanwhile, one DEG is significantly related to short disease-free survival, four are associated with overall survival, and 12 DEGs have close ties with tumor staging. Additionally, the SP110 is significantly associated with methylation level, HPV status, tumor staging, gender, race, tumor grade, age, and overall/disease-free survival of oral cancer patients, as well as the immune process. The copy number variation of SP110 significantly affected the abundance of immune infiltration. Therefore, we speculate that SP110 could be used as the diagnostic and therapeutic biomarker for OSCC, and can help to further understand oral carcinogenesis.
摘要：
口腔鳞状细胞癌(OSCC)的发病率逐年上升,使其成为一个重大的全球健康问题。但OSCC的分子发病机制目前尚不清楚。为了研究OSCC的潜在发病机制，筛选差异表达基因(DEGs),并且使用多个数据库来执行肿瘤分期，表达式,预后,蛋白质-蛋白质相互作用(PPI)网络，模块，和功能富集分析。此外，我们已将SP110确定为关键候选基因,并使用多个数据库对其进行了各种分析.研究表明，共有211个常见的DEG，它们丰富了各种GO术语和途径。同时,一个DEG与无病生存期短显著相关，四个与总生存率相关，12个DEGs与肿瘤分期有密切关系。此外,SP110与甲基化水平显着相关，HPV状态，肿瘤分期,性别,种族,肿瘤分级,年龄,以及口腔癌患者的总体/无病生存率，以及免疫过程。SP110的拷贝数变异显著影响免疫浸润丰度。因此,我们推测SP110可以作为OSCC的诊断和治疗生物标志物，并有助于进一步了解口腔癌的发生。
