Abstract：
The purpose of the present study was to estimate the factors linked to the prognosis of children with provisional tic disorder (PTD). We conducted a prospective cohort study enrolled children with PTD who were subsequently followed-up at three-month intervals for 1 year post-enrolment. A total of 259 PTD patients were included in the final analysis. At the end of the follow-up period, 77 (30%) of the patients had achieved clinical remission. Result of the LASSO logistic regression analysis revealed that a disease duration >3 months (OR=4.20, 95% CI 1.20-14.73), moderate/severe tic severity (OR=5.57, 95% CI 2.26-13.76), and comorbid behavioral problems (OR=2.78, 95% CI 1.15-6.69) were significant factors linked to remission in the PTD patients. The path analysis model showed that comorbid behavioral problems and recurrence partially mediated the association between tic severity and remission, with a mediating effect of 37%. Conclusions: We have identified several significant factors linked to prognosis in children with PTD, including comorbid behavioral problems and recurrence, which were found to be important mediators. These findings provide new insights for the clinical management of patients with PTD.
摘要：
本研究的目的是评估与暂时性抽动障碍（PTD）儿童预后相关的因素。我们进行了一项前瞻性队列研究，纳入了PTD患儿，随后在入组后1年内间隔三个月进行随访。共有259名PTD患者被纳入最终分析。在随访期结束时，77（30％）的患者已实现临床缓解。LASSOlogistic回归分析结果显示病程>3个月(OR=4.20,95%CI1.20-14.73),中度/重度抽动严重程度（OR=5.57，95%CI2.26-13.76），和合并症行为问题（OR=2.78，95％CI1.15-6.69）是与PTD患者缓解相关的重要因素。路径分析模型显示，共病行为问题和复发部分介导了抽搐严重程度和缓解之间的关联，具有37%的中介效应。结论：我们已经确定了与PTD儿童预后相关的几个重要因素，包括合并症行为问题和复发，被发现是重要的调解人。这些发现为PTD患者的临床管理提供了新的见解。
