Abstract：
The present systematic review (SR) aims to evaluate manuscripts in order to help further elucidate the following question: is the micronucleus assay (MA) also a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage in vivo? A search was performed through the electronic databases PubMed/Medline, Scopus, and Web of Science, all studies published up to December 2023. The comparisons were defined as standardized mean difference (SMD), and 95% confidence intervals (CIs) were established. Full manuscripts from 34 studies were carefully selected and reviewed in this setting. Our results demonstrate that the MA may be a useful biomarker of gingival tissue damage in vivo, and this tissue could be a useful alternative to the buccal mucosa. The meta-analysis analyzing the different sites regardless of the deleterious factor studied, the buccal mucosa (SMD = 0.69, 95% CI, - 0.49 to 1.88, p = 0.25) and gingiva (SMD = 0.31, 95% CI, - 0.11 to 0.72, p = 0.15), showed similar results and different outcome for the tongue (SMD = 1.19, 95% CI, 0.47 to 1.91, p = 0.001). In summary, our conclusion suggests that the MA can be a useful marker for detecting DNA damage in gingiva in vivo and that this tissue could be effective site for smearing.
摘要：
本系统综述（SR）旨在评估手稿，以帮助进一步阐明以下问题：微核测定（MA）是否也是牙龈中的有用标记，舌头,和评估体内细胞遗传学损伤的腭？通过电子数据库PubMed/Medline进行了搜索，Scopus,和WebofScience,截至2023年12月发表的所有研究。比较定义为标准化平均差(SMD)，建立95%置信区间(CI)。在此设置中仔细选择和审查了34项研究的完整手稿。我们的结果表明，MA可能是体内牙龈组织损伤的有用生物标志物，这种组织可能是颊粘膜的有用替代品。荟萃分析分析不同的网站，而不考虑所研究的有害因素，颊粘膜（SMD=0.69，95％CI，-0.49至1.88，p=0.25）和牙龈（SMD=0.31，95％CI，-0.11至0.72，p=0.15），舌头显示出相似的结果和不同的结果（SMD=1.19，95％CI，0.47至1.91，p=0.001）。总之,我们的结论表明，MA可能是体内检测牙龈DNA损伤的有用标记，并且该组织可能是涂片的有效部位。
