Abstract：
Supramolecular materials have been assembled using a wide range of interactions, including the hydrophobic effect, DNA base-pairing, and hydrogen bonding. Specifically, DNA amphiphiles with a hydrophobic building block self-assemble into diverse morphologies depending on the length and composition of both blocks. Herein, we take advantage of the orthogonality of different supramolecular interactions - the hydrophobic effect, Watson-Crick-Franklin base pairing and RNA kissing loops - to create hierarchical self-assemblies with controlled morphologies on both the nanometer and the micrometer scales. Assembly through base-pairing leads to the formation of hybrid, multi-phasic hydrogels with high stiffness and self-healing properties. Assembly via hydrophobic core interactions gives anisotropic, discrete assemblies, where DNA fibers with one sequence are terminated with DNA spheres bearing different sequences. This work opens new avenues for the bottom-up construction of DNA-based materials, with promising applications in drug delivery, tissue engineering, and the creation of complex DNA structures from a minimum array of components.
摘要：
超分子材料已经使用广泛的相互作用进行组装，包括疏水效应，DNA碱基配对,和氢键。具体来说,具有疏水性结构单元的DNA两亲物根据两个嵌段的长度和组成自组装成不同的形态。在这里，我们利用不同超分子相互作用的正交性-疏水效应，Watson-Crick-Franklin碱基配对和RNA接吻环-在纳米和微米尺度上创建具有受控形态的分层自组装体。通过碱基配对组装导致杂种的形成，具有高刚度和自修复性能的多相水凝胶。通过疏水核心相互作用的组装给出各向异性，离散组件，其中具有一个序列的DNA纤维终止于具有不同序列的DNA球体。这项工作为自下而上构建基于DNA的材料开辟了新的途径，在药物输送中具有广阔的应用前景，组织工程,以及从最少的组件阵列中创建复杂的DNA结构。
