METHODS: Meta-analyses and comprehensive syntheses were used to thoroughly review, compile, and summarize the complete body of relevant evidence. All studies were meticulously assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method, and the outcomes were presented succinctly as evidence profiles. Those evidence syntheses were discussed by a multidisciplinary committee of experts in mechanical ventilation, who then developed and approved recommendations.
RESULTS: Recommendations for nine population, intervention, comparator, outcome (PICO) questions about ventilator liberation are presented in this document. This guideline includes seven conditional recommendations, one expert consensus recommendation, and one conditional deferred recommendation.
CONCLUSIONS: We developed these clinical guidelines for mechanical ventilation liberation to provide meaningful recommendations. These guidelines reflect the best treatment for patients seeking liberation from mechanical ventilation.
方法:采用荟萃分析和综合综合分析,compile,并总结完整的相关证据。所有研究都使用建议分级进行了仔细评估,评估,发展,和评估(等级)方法,结果被简洁地呈现为证据概况。这些证据综合由机械通气的多学科专家委员会讨论,然后,他们制定并批准了建议。
结果:针对9个人群的建议,干预,比较器,本文件介绍了有关呼吸机解放的结果(PICO)问题。本指南包括七个有条件的建议,一项专家共识建议,和一个有条件的推迟建议。
结论:我们制定了这些机械通气释放的临床指南,以提供有意义的建议。这些指南反映了寻求从机械通气中解放出来的患者的最佳治疗方法。