Abstract：
This study aimed to explore whether there is an association between environmental exposure to POPs and kidney tumor induction, and whether blood POP concentrations reflect kidney tissue concentrations. POP derivatives were determined in blood, tumor tissue, tumor surrounding tissue, and perirenal fat tissue samples taken from patients who underwent surgery for renal tumors. A voluntary control group was recruited for blood and urine samples as well. Urinary excretions of o,o\'-dityrosine, chlorotyrosine, nitrotyrosine, and 8-OHdG were measured in the same patients. The possible role of genetic polymorphisms in CYP1A1, GST isozymes P, M, and T, and hOGG1 genes on the predisposition to renal cancer was investigated. Some POPs have been found to be associated with kidney cancer, as evidenced by their significantly high ORs. 8-OHdG levels were significantly higher compared to the control group. The GSTT1 null polymorphism can be a risk factor for malignant but not for benign kidney tumors.
摘要：
本研究旨在探讨环境暴露于POPs与肾肿瘤诱导之间是否存在关联。以及血液POP浓度是否反映肾组织浓度。在血液中测定POP衍生物，肿瘤组织，肿瘤周围组织，和肾肿瘤手术患者的肾周脂肪组织样本。还招募了自愿对照组进行血液和尿液样本。尿排泄物o，o\'-二酪氨酸,氯酪氨酸,硝基酪氨酸，在同一患者中测量8-OHdG。遗传多态性在CYP1A1，GST同工酶P，M,T,和hOGG1基因对肾癌的易感性进行了研究。一些持久性有机污染物被发现与肾癌有关，其显著高的OR证明。8-OHdG水平明显高于对照组。GSTT1无效多态性可能是恶性而不是良性肾脏肿瘤的危险因素。
