Abstract：
The current pharmacological management of androgenetic alopecia is inconvenient and requires a discipline that patients find difficult to follow. This reduces compliance with treatment and satisfaction with results. It is important to propose treatment regimens that increase patient compliance and reduce adverse effects. This work describes transdermal delivery of minoxidil partially encapsulated in β-cyclodextrin and assisted by photoacoustic waves. Photoacoustic waves transiently increase the permeability of the skin and allow for the delivery of encapsulated minoxidil. A minoxidil gel formulation was developed and the transdermal delivery was studied in vitro in the presence and absence of photoacoustic waves. A 5-min stimulus with photoacoustic waves generated by light-to-pressure transducers increases minoxidil transdermal delivery flux by approximately 3-fold. The flux of a 1% minoxidil formulation promoted by photoacoustic waves is similar to the passive flux of a 2% minoxidil commercial formulation. Release of minoxidil from β-cyclodextrin increases dermal exposure without increasing peak systemic exposure. This promotes hair growth with fewer treatments and reduced adverse effects. In vivo studies using encapsulated minoxidil and photoacoustic waves yielded 86% hair coat recovery (vs. 29% in the control group) and no changes in the blood pressure.
摘要：
目前雄激素性脱发的药理学管理不方便，需要患者难以遵循的学科。这降低了对治疗的依从性和对结果的满意度。重要的是提出增加患者依从性和减少不良反应的治疗方案。这项工作描述了部分包封在β-环糊精中并通过光声波辅助的米诺地尔的透皮递送。光声波瞬时增加皮肤的渗透性并允许递送包封的米诺地尔。开发了米诺地尔凝胶制剂，并在存在和不存在光声波的情况下进行了体外透皮给药研究。由光-压力换能器产生的光声波的5分钟刺激使米诺地尔透皮递送通量增加约3倍。由光声波促进的1%米诺地尔制剂的通量类似于2%米诺地尔商业制剂的被动通量。米诺地尔从β-环糊精的释放增加了皮肤暴露,而不增加峰值全身暴露。这促进了头发生长，减少了治疗和副作用。使用封装的米诺地尔和光声波的体内研究产生了86％的头发外套恢复（与对照组为29％），血压无变化。
