Abstract：
While lasers have found their successful applications in various clinical specialties, in clinical dental practice, traditional mechanical drills are still predominantly utilized. Although erbium-doped lasers have been demonstrated for dental therapy, their clinical performance is still not satisfactory due to the long pulse width, low peak power, and small repetition rate. To attain a smaller thermal diffusion thus better biological safety and surgical precision, as well as more rapid ablation, the advancement of femtosecond laser techniques has opened another route of dental surgery; however, no biological safety investigation has been reported. Here, we present a systematic study of dental ablation by a Yb:CaAlGdO4 regenerative amplifier with a central wavelength of 1040 nm and pulse width of 160 fs. The in vivo experiment of dental surgery investigating the inflammatory response has been reported, for the first time to the best of our knowledge. It is demonstrated that dental surgery by Yb:CaAlGdO4 femtosecond laser ablation has better biological safety compared to the turbine drilling, thanks to its non-contact and ultrafast heat dissipation nature.
摘要：
虽然激光已经在各种临床专业中找到了成功的应用，在临床牙科实践中，传统的机械钻头仍然主要使用。虽然掺铒激光器已被证明可用于牙科治疗，由于脉冲宽度较长，其临床表现仍不令人满意，低峰值功率，和小重复率。为了获得更小的热扩散，从而获得更好的生物安全性和手术精度，以及更快速的消融，飞秒激光技术的进步为牙科手术开辟了另一条道路；然而，没有生物安全性调查的报道。这里,我们通过Yb：CaAlGdO4再生放大器对牙齿消融进行了系统的研究，该放大器的中心波长为1040nm，脉冲宽度为160fs。已经报道了牙科手术研究炎症反应的体内实验，据我们所知，这是第一次。结果表明，与涡轮钻孔相比，Yb：CaAlGdO4飞秒激光烧蚀牙科手术具有更好的生物安全性，由于其非接触和超快散热性质。
