Abstract：
Millions of people worldwide are affected by leishmaniasis, caused by the Leishmania parasite. Effective treatment is challenging due to the biological complexity of the parasite, drug toxicity, and increasing resistance to conventional drugs. To combat this disease, the development of specific strategies to target and selectively eliminate the parasite is crucial. This Review highlights the importance of amino acids in the developmental stages of Leishmania as a factor determining whether the infection progresses or is suppressed. It also explores the use of peptides as alternatives in parasite control and the development of novel targeted treatments. While these strategies show promise for more effective and targeted treatment, further studies to address the remaining challenges are imperative.
摘要：
全世界数百万人受到利什曼病的影响，是由利什曼原虫寄生虫引起的.由于寄生虫的生物复杂性，有效的治疗具有挑战性，药物毒性，并增加对常规药物的耐药性。为了对抗这种疾病,制定针对和选择性消除寄生虫的特定策略至关重要。这篇综述强调了氨基酸在利什曼原虫发育阶段的重要性，作为决定感染是否进展或被抑制的因素。它还探索了使用肽作为寄生虫控制和新型靶向治疗的替代品。虽然这些策略显示出更有效和有针对性的治疗前景，必须进一步研究以应对剩余的挑战。
