PDF(Pubmed)
Abstract：
Mitochondrial shape and network formation have been primarily associated with the well-established processes of fission and fusion. However, recent research has unveiled an intricate and multifaceted landscape of mitochondrial morphology that extends far beyond the conventional fission-fusion paradigm. These less-explored dimensions harbor numerous unresolved mysteries. This review navigates through diverse processes influencing mitochondrial shape and network formation, highlighting the intriguing complexities and gaps in our understanding of mitochondrial architecture. The exploration encompasses various scales, from biophysical principles governing membrane dynamics to molecular machineries shaping mitochondria, presenting a roadmap for future research in this evolving field.
摘要：
线粒体形状和网络形成主要与已建立的裂变和融合过程有关。然而,最近的研究揭示了线粒体形态的复杂和多方面的景观，远远超出了传统的裂变融合范式。这些较少探索的维度藏有许多未解决的谜团。这篇综述浏览了影响线粒体形状和网络形成的各种过程，突出了我们对线粒体结构的理解中有趣的复杂性和差距。探索包括各种规模，从控制膜动力学的生物物理原理到塑造线粒体的分子机制，为这一不断发展的领域的未来研究提供了路线图。
