Abstract：
UNASSIGNED: Acute pain episodes, also known as vaso-occlusive crises (VOC), are a major symptom of sickle cell disease (SCD) and lead to frequent hospitalizations. The diagnosis of VOC can be challenging, particularly in adults with SCD, 50% of whom have chronic pain. Several potential biomarkers have been proposed for identifying individuals with VOC, including elevation above the baseline of various vascular growth factors, cytokines, and other markers of inflammation. However, none have been validated to date.
UNASSIGNED: We summarize prospective biomarkers for the diagnosis of acute pain in SCD, and how they may be involved in the pathophysiology of a VOC. Previous and current strategies for biomarker discovery, including the use of omics techniques, are discussed.
UNASSIGNED: Implementing a multi-omics-based approach will facilitate the discovery of objective and validated biomarkers for acute pain.
UNASSIGNED: We summarize prospective biomarkers for the diagnosis of acute pain in SCD, and how they may be involved in the pathophysiology of a VOC. Previous and current strategies for biomarker discovery, including the use of omics techniques, are discussed.
UNASSIGNED: Implementing a multi-omics-based approach will facilitate the discovery of objective and validated biomarkers for acute pain.
摘要：
■急性疼痛发作，也称为血管闭塞危象（VOC），是镰状细胞病（SCD）的主要症状，并导致频繁住院。VOC的诊断可能具有挑战性，特别是在患有SCD的成年人中，其中50%患有慢性疼痛。已经提出了几种潜在的生物标志物用于鉴定患有VOC的个体，包括各种血管生长因子的基线以上的升高，细胞因子,和其他炎症标志物。然而,到目前为止还没有验证。
■我们总结了诊断SCD急性疼痛的前瞻性生物标志物，以及它们如何参与VOC的病理生理学。生物标志物发现的先前和当前策略，包括使用组学技术，正在讨论。
■实施基于多组学的方法将有助于发现客观和有效的急性疼痛生物标志物。
■我们总结了诊断SCD急性疼痛的前瞻性生物标志物，以及它们如何参与VOC的病理生理学。生物标志物发现的先前和当前策略，包括使用组学技术，正在讨论。
■实施基于多组学的方法将有助于发现客观和有效的急性疼痛生物标志物。
