Abstract：
The interest in wound dressings increased ten years ago. Wound care practitioners can now use interactive/bioactive dressings and tissue-engineered skin substitutes. Several bandages can heal burns, but none can treat all chronic wounds. This study formulates a composite material from 70% polyvinyl alcohol (PVA) and 30% polyethylene glycol (PEG) with 0.2, 0.4, and 0.6 wt% magnesium oxide nanoparticles. This study aims to create a biodegradable wound dressing. A Fourier Transform Infrared (FTIR) study shows that PVA, PEG, and MgO create hydrogen bonding interactions. Hydrophilic characteristics are shown by the polymeric blend\'s 56.289° contact angle. MgO also lowers the contact angle, making the film more hydrophilic. Hydrophilicity improves film biocompatibility, live cell adhesion, wound healing, and wound dressing degradability. Differential Scanning Calorimeter (DSC) findings suggest the PVA/PEG combination melted at 53.16 °C. However, adding different weight fractions of MgO nanoparticles increased the nanocomposite\'s melting temperature (Tm). These nanoparticles improve the film\'s thermal stability, increasing Tm. In addition, MgO nanoparticles in the polymer blend increased tensile strength and elastic modulus. This is due to the blend\'s strong adherence to the reinforcing phase and MgO nanoparticles\' ceramic material which has a great mechanical strength. The combination of 70% PVA + 30% PEG exhibited good antibacterial spatially at 0.2% MgO, according to antibacterial test results.
摘要：
十年前，人们对伤口敷料的兴趣有所增加。伤口护理从业者现在可以使用交互式/生物活性敷料和组织工程皮肤替代品。几个绷带可以治愈烧伤，但没有人能治疗所有慢性伤口.本研究由70％聚乙烯醇（PVA）和30％聚乙二醇（PEG）与0.2、0.4和0.6wt％氧化镁纳米颗粒配制复合材料。本研究旨在创造一种可生物降解的伤口敷料。傅里叶变换红外(FTIR)研究表明,PEG，和MgO产生氢键相互作用。亲水特性由聚合物共混物的56.289°接触角显示。MgO也降低了接触角，使薄膜更亲水。亲水性提高薄膜生物相容性，活细胞粘附，伤口愈合，和伤口敷料降解性。差示扫描量热计(DSC)结果表明PVA/PEG组合在53.16°C熔融。然而,添加不同重量分数的MgO纳米颗粒提高了纳米复合材料的熔融温度(Tm)。这些纳米粒子提高了薄膜的热稳定性，增加Tm。此外,聚合物共混物中的MgO纳米颗粒增加了拉伸强度和弹性模量。这是由于共混物对增强相和具有很大机械强度的MgO纳米颗粒陶瓷材料的强粘附性。70%PVA+30%PEG的组合在0.2%MgO下表现出良好的空间抗菌性,根据抗菌试验结果。
