Abstract：
UNASSIGNED: The aim of this study was to investigate the efficacy of calcitonin (CT) in animal models of experimental osteoarthritis (OA) and rheumatoid arthritis (RA), as new stabilized CT formulations are currently being introduced.
UNASSIGNED: A comprehensive and systemic literature search was conducted in PubMed/MEDLINE and Embase databases to identify articles with original data on CT treatment of preclinical OA and RA. Methodological quality was assessed using the Systematic Review Centre for Laboratory Animal Experimentation\'s risk of bias tool for animal intervention studies. To provide summary estimates of efficacy, a meta-analysis was conducted for outcomes reported in four or more studies, using a random-effects model. Subgroup analyses were employed to correct for study specifics.
UNASSIGNED: Twenty-six studies were ultimately evaluated and data from 16 studies could be analyzed in the meta-analysis, which included the following outcomes: bone mineral density, bone volume, levels of cross-linked C-telopeptide of type I collagen, histopathological arthritis score, and mechanical allodynia. For all considered outcome parameters, CT-treated groups were significantly superior to control groups (P = 0.002; P = 0.01; P < 0.00001; P < 0.00001; P = 0.04). For most outcomes, effect sizes were significantly greater in OA than in RA (P ≤ 0.025). High in-between study heterogeneity was detected.
UNASSIGNED: There is preclinical evidence for an antioxidant, anti-inflammatory, antinociceptive, cartilage- and bone-protective effect of CT in RA and OA. Given these effects, CT presents a promising agent for the treatment of both diseases, although the potential seems to be greater in OA.
UNASSIGNED: A comprehensive and systemic literature search was conducted in PubMed/MEDLINE and Embase databases to identify articles with original data on CT treatment of preclinical OA and RA. Methodological quality was assessed using the Systematic Review Centre for Laboratory Animal Experimentation\'s risk of bias tool for animal intervention studies. To provide summary estimates of efficacy, a meta-analysis was conducted for outcomes reported in four or more studies, using a random-effects model. Subgroup analyses were employed to correct for study specifics.
UNASSIGNED: Twenty-six studies were ultimately evaluated and data from 16 studies could be analyzed in the meta-analysis, which included the following outcomes: bone mineral density, bone volume, levels of cross-linked C-telopeptide of type I collagen, histopathological arthritis score, and mechanical allodynia. For all considered outcome parameters, CT-treated groups were significantly superior to control groups (P = 0.002; P = 0.01; P < 0.00001; P < 0.00001; P = 0.04). For most outcomes, effect sizes were significantly greater in OA than in RA (P ≤ 0.025). High in-between study heterogeneity was detected.
UNASSIGNED: There is preclinical evidence for an antioxidant, anti-inflammatory, antinociceptive, cartilage- and bone-protective effect of CT in RA and OA. Given these effects, CT presents a promising agent for the treatment of both diseases, although the potential seems to be greater in OA.
摘要：
■这项研究的目的是研究降钙素（CT）在实验性骨关节炎（OA）和类风湿性关节炎（RA）的动物模型中的功效，由于目前正在引入新的稳定CT制剂。
■在PubMed/MEDLINE和Embase数据库中进行全面和系统的文献检索，以确定具有CT治疗临床前OA和RA的原始数据的文章。使用实验动物实验系统评价中心的偏倚风险工具进行动物干预研究，评估方法学质量。为了提供疗效的汇总估计，对四项或更多研究报告的结果进行了荟萃分析，使用随机效应模型。采用亚组分析来校正研究细节。
■最终评估了26项研究，16项研究的数据可以在荟萃分析中进行分析，其中包括以下结果：骨矿物质密度，骨体积,I型胶原蛋白的交联C端肽水平，组织病理学关节炎评分，和机械性异常性疼痛。对于所有考虑的结果参数，CT治疗组明显优于对照组(P=0.002;P=0.01;P<0.00001;P<0.00001;P=0.04)。对于大多数结果，OA的效应大小显著大于RA(P≤0.025).检测到高的研究间异质性。
■有抗氧化剂的临床前证据，抗炎,抗伤害性,CT在RA和OA中的软骨和骨保护作用。鉴于这些影响，CT为这两种疾病的治疗提供了一种有前途的药物，虽然在OA中的潜力似乎更大。
■在PubMed/MEDLINE和Embase数据库中进行全面和系统的文献检索，以确定具有CT治疗临床前OA和RA的原始数据的文章。使用实验动物实验系统评价中心的偏倚风险工具进行动物干预研究，评估方法学质量。为了提供疗效的汇总估计，对四项或更多研究报告的结果进行了荟萃分析，使用随机效应模型。采用亚组分析来校正研究细节。
■最终评估了26项研究，16项研究的数据可以在荟萃分析中进行分析，其中包括以下结果：骨矿物质密度，骨体积,I型胶原蛋白的交联C端肽水平，组织病理学关节炎评分，和机械性异常性疼痛。对于所有考虑的结果参数，CT治疗组明显优于对照组(P=0.002;P=0.01;P<0.00001;P<0.00001;P=0.04)。对于大多数结果，OA的效应大小显著大于RA(P≤0.025).检测到高的研究间异质性。
■有抗氧化剂的临床前证据，抗炎,抗伤害性,CT在RA和OA中的软骨和骨保护作用。鉴于这些影响，CT为这两种疾病的治疗提供了一种有前途的药物，虽然在OA中的潜力似乎更大。
