PDF(Pubmed)
Abstract：
Type 3 innate lymphoid cells (ILC3s) are key regulators of intestinal homeostasis and epithelial barrier integrity. In this issue of the JCI, Cao and colleagues found that a sensor of endoplasmic reticulum (ER) stress, the inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1) pathway, fine-tuned the functions of ILC3s. Activation of IRE1α and XBP1 in ILC3s limited intestinal inflammation in mice and correlated with the efficacy of ustekinumab, an IL-12/IL-23 blocker, in patients with Crohn\'s disease. These results advance our understanding in the use of ILCs as biomarkers not only to predict disease outcomes but also to indicate the response to biologicals in patients with inflammatory bowel disease.
摘要：
3型先天淋巴细胞（ILC3）是肠道稳态和上皮屏障完整性的关键调节因子。在本期JCI中，Cao和他的同事们发现了内质网（ER）应激的传感器，需要肌醇的激酶1α/X-盒结合蛋白1（IRE1α/XBP1）途径，对ILC3的功能进行了微调。IRE1α和XBP1在ILC3s限制小鼠肠道炎症中的激活，并与ustekinumab的疗效相关，IL-12/IL-23阻断剂，克罗恩病患者。这些结果促进了我们对使用ILC作为生物标志物的理解，不仅可以预测疾病结果，而且可以指示炎症性肠病患者对生物制剂的反应。
