Abstract：
BACKGROUND: Although reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume (WMHV), a key indicator of cerebral small vessel disease. Even fewer studies consider estrone (E1), the primary postmenopausal estrogen, or follicle-stimulating hormone (FSH), an indicator of ovarian age. We tested associations of estradiol (E2), E1, and FSH to WMHV among women.
METHODS: Two hundred twenty-two women (mean age = 59) underwent hormone assays (E1, E2, FSH) and 3T brain magnetic resonance imaging. Associations of hormones to WMHV were tested with linear regression.
RESULTS: Higher E2 (B[standard error (SE)] = -0.17[0.06], P = 0.008) and E1 (B[SE] = -0.26[0.10], P = 0.007) were associated with lower whole-brain WMHV, and higher FSH (B[SE] = 0.26[0.07], P = 0.0005) with greater WMHV (covariates age, race, education). When additionally controlling for cardiovascular disease risk factors, associations of E1 and FSH to WMHV remained.
CONCLUSIONS: Reproductive hormones, particularly E1 and FSH, are important to women\'s cerebrovascular health.
CONCLUSIONS: Despite widespread belief that sex hormones are important to women\'s brain health, little work has considered how these hormones in women relate to white matter hyperintensities (WMH), a major indicator of cerebral small vessel disease. We considered relations of estradiol (E2), estrone (E1), and follicle-stimulating hormone (FSH) to WMH in midlife women. Higher E2 and E1 were associated with lower whole-brain WMH volume (WMHV), and higher FSH with higher whole-brain WMHV. Associations of E1 and FSH, but not E2, to WMHV persisted with adjustment for cardiovascular disease risk factors. Findings underscore the importance of E2 and FSH to women\'s cerebrovascular health.
METHODS: Two hundred twenty-two women (mean age = 59) underwent hormone assays (E1, E2, FSH) and 3T brain magnetic resonance imaging. Associations of hormones to WMHV were tested with linear regression.
RESULTS: Higher E2 (B[standard error (SE)] = -0.17[0.06], P = 0.008) and E1 (B[SE] = -0.26[0.10], P = 0.007) were associated with lower whole-brain WMHV, and higher FSH (B[SE] = 0.26[0.07], P = 0.0005) with greater WMHV (covariates age, race, education). When additionally controlling for cardiovascular disease risk factors, associations of E1 and FSH to WMHV remained.
CONCLUSIONS: Reproductive hormones, particularly E1 and FSH, are important to women\'s cerebrovascular health.
CONCLUSIONS: Despite widespread belief that sex hormones are important to women\'s brain health, little work has considered how these hormones in women relate to white matter hyperintensities (WMH), a major indicator of cerebral small vessel disease. We considered relations of estradiol (E2), estrone (E1), and follicle-stimulating hormone (FSH) to WMH in midlife women. Higher E2 and E1 were associated with lower whole-brain WMH volume (WMHV), and higher FSH with higher whole-brain WMHV. Associations of E1 and FSH, but not E2, to WMHV persisted with adjustment for cardiovascular disease risk factors. Findings underscore the importance of E2 and FSH to women\'s cerebrovascular health.
摘要：
背景：尽管生殖激素与女性脑小血管病有关，很少有研究考虑测量的激素与白质高强度体积(WMHV)的关系，脑小血管病的关键指标。更少的研究考虑雌酮（E1），绝经后的主要雌激素，或卵泡刺激素（FSH），卵巢年龄的指标。我们测试了雌二醇（E2）的关联，女性中的E1和FSH至WMHV。
方法：22名女性（平均年龄=59岁）接受了激素检测（E1，E2，FSH）和3T脑磁共振成像。用线性回归测试激素与WMHV的关联。
结果：较高的E2（B[标准误差（SE）]=-0.17[0.06]，P=0.008）和E1（B[SE]=-0.26[0.10]，P=0.007）与较低的全脑WMHV相关，和更高的FSH(B[SE]=0.26[0.07]，P=0.0005)具有更大的WMHV(协变量年龄，种族,education).当额外控制心血管疾病危险因素时，E1和FSH与WMHV的相关性仍然存在。
结论：生殖激素，特别是E1和FSH，对女性的脑血管健康很重要。
结论：尽管人们普遍认为性激素对女性的大脑健康很重要，很少有工作考虑女性的这些激素如何与白质高信号（WMH）相关，脑小血管病的主要指标。我们考虑了雌二醇（E2）的关系，雌酮（E1），和卵泡刺激素（FSH）对中年女性的WMH。较高的E2和E1与较低的全脑WMH体积（WMHV）相关，FSH较高，全脑WMHV较高。E1和FSH的关联，而不是E2，WMHV持续调整心血管疾病危险因素。研究结果强调了E2和FSH对女性脑血管健康的重要性。
方法：22名女性（平均年龄=59岁）接受了激素检测（E1，E2，FSH）和3T脑磁共振成像。用线性回归测试激素与WMHV的关联。
结果：较高的E2（B[标准误差（SE）]=-0.17[0.06]，P=0.008）和E1（B[SE]=-0.26[0.10]，P=0.007）与较低的全脑WMHV相关，和更高的FSH(B[SE]=0.26[0.07]，P=0.0005)具有更大的WMHV(协变量年龄，种族,education).当额外控制心血管疾病危险因素时，E1和FSH与WMHV的相关性仍然存在。
结论：生殖激素，特别是E1和FSH，对女性的脑血管健康很重要。
结论：尽管人们普遍认为性激素对女性的大脑健康很重要，很少有工作考虑女性的这些激素如何与白质高信号（WMH）相关，脑小血管病的主要指标。我们考虑了雌二醇（E2）的关系，雌酮（E1），和卵泡刺激素（FSH）对中年女性的WMH。较高的E2和E1与较低的全脑WMH体积（WMHV）相关，FSH较高，全脑WMHV较高。E1和FSH的关联，而不是E2，WMHV持续调整心血管疾病危险因素。研究结果强调了E2和FSH对女性脑血管健康的重要性。
