PDF(Pubmed)
Abstract：
Flagella are highly complex rotary molecular machines that enable bacteria to not only migrate to optimal environments but to also promote range expansion, competitiveness, virulence, and antibiotic survival. Flagellar motility is an energy-demanding process, where the sum of its production (biosynthesis) and operation (rotation) costs has been estimated to total ~10% of the entire energy budget of an E. coli cell. The acquisition of such a costly adaptation process is expected to secure short-term benefits by increasing competitiveness and survival, as well as long-term evolutionary fitness gains. While the role of flagellar motility in bacterial survival has been widely reported, its direct influence on the rate of evolution remains unclear. We show here that both production and operation costs contribute to elevated mutation frequencies. Our findings suggest that flagellar movement may be an important player in tuning the rate of bacterial evolution.
摘要：
Flagella是高度复杂的旋转分子机器，使细菌不仅可以迁移到最佳环境，还可以促进范围扩展，竞争力,毒力,抗生素生存鞭毛运动是一个需要能量的过程，其中，其生产（生物合成）和操作（轮换）成本的总和估计为大肠杆菌细胞总能量预算的10%。获得这样一个代价高昂的适应过程，预计将通过提高竞争力和生存能力来获得短期利益，以及长期的进化适应度增益。虽然鞭毛运动在细菌存活中的作用已被广泛报道，其对进化速度的直接影响尚不清楚。我们在这里表明，生产和运营成本都会导致突变频率升高。我们的发现表明鞭毛运动可能是调节细菌进化速度的重要参与者。
