PDF(Pubmed)
Abstract：
UNASSIGNED: The Sunderban area of West Bengal is home to tribal and religious minorities inhabiting various islands. There is a high prevalence of thalassemia among poverty-stricken residents of this region living with meagre health care facilities. This work was planned to determine the proportion of four viral transfusion-transmitted infections (TTIs): HIV-1, HIV-2, hepatitis B virus (HBV) and hepatitis C virus (HCV) among thalassemia patients attending the sole rural medical college in the region.
UNASSIGNED: Thalassemia patients (n = 359, age ranging from 1 year to 60 years) attending the thalassemia clinic or being admitted to the indoor facilities for better management were included in the study. Only patients diagnosed with high-performance liquid chromatography (HPLC) and with classical clinical features were included in the study. Blood samples of these patients were tested for HIV as per NACO protocol. For HBV and HCV, samples were first tested serologically; reactive samples were collected and sent in the cold chain to a higher centre for nucleic acid amplification testing (NAAT) for qualitative and quantitative estimation. Clinical and laboratory data was collected, patients were followed up for complications and hospitalisation during the study period, and statistical analysis was performed.
UNASSIGNED: Majority of our patients had E-beta-thalassemia (245, 59.81%), followed by beta-thalassemia major (102, 28.30%). NAAT-confirmed HCV infection (14.21%) infection was the most common, followed by HBV (2.51%), and lastly by HIV-1 (0.58%) infection. Among infected thalassemia patients, the mean HCV RNA was 741063 ± 438514.67 IU/ml while the mean HBV DNA level was 4082863 ± 7298514 IU/ml. Co-infections of HIV-1 and HCV and that of HBV and HCV were noted in one patient each (0.28%). HCV-related liver disease (14.21%) and growth retardation (10.31%) were the most typical complication noted, and death occurred in five patients (1.39%) during the study period.
UNASSIGNED: Primary care physicians should know HCV infection is the most common TTI among thalassemia patients in rural eastern India.
UNASSIGNED: Thalassemia patients (n = 359, age ranging from 1 year to 60 years) attending the thalassemia clinic or being admitted to the indoor facilities for better management were included in the study. Only patients diagnosed with high-performance liquid chromatography (HPLC) and with classical clinical features were included in the study. Blood samples of these patients were tested for HIV as per NACO protocol. For HBV and HCV, samples were first tested serologically; reactive samples were collected and sent in the cold chain to a higher centre for nucleic acid amplification testing (NAAT) for qualitative and quantitative estimation. Clinical and laboratory data was collected, patients were followed up for complications and hospitalisation during the study period, and statistical analysis was performed.
UNASSIGNED: Majority of our patients had E-beta-thalassemia (245, 59.81%), followed by beta-thalassemia major (102, 28.30%). NAAT-confirmed HCV infection (14.21%) infection was the most common, followed by HBV (2.51%), and lastly by HIV-1 (0.58%) infection. Among infected thalassemia patients, the mean HCV RNA was 741063 ± 438514.67 IU/ml while the mean HBV DNA level was 4082863 ± 7298514 IU/ml. Co-infections of HIV-1 and HCV and that of HBV and HCV were noted in one patient each (0.28%). HCV-related liver disease (14.21%) and growth retardation (10.31%) were the most typical complication noted, and death occurred in five patients (1.39%) during the study period.
UNASSIGNED: Primary care physicians should know HCV infection is the most common TTI among thalassemia patients in rural eastern India.
摘要：
■西孟加拉邦的桑德班地区是居住在各个岛屿上的部落和宗教少数群体的家园。该地区生活在薄弱的医疗保健设施中的贫困居民地中海贫血患病率很高。这项工作旨在确定参加该地区唯一农村医学院的地中海贫血患者中四种病毒输血传播感染（TTI）的比例：HIV-1，HIV-2，乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）。
■地中海贫血患者（n=359，年龄从1岁到60岁不等）在地中海贫血诊所就诊或为了更好的管理而进入室内设施被纳入研究。本研究仅包括经高效液相色谱（HPLC）诊断并具有经典临床特征的患者。根据NACO方案对这些患者的血液样本进行HIV测试。对于HBV和HCV，首先对样品进行血清学检测;收集反应性样品并将其在冷链中送往较高的核酸扩增检测中心(NAAT)进行定性和定量评估.收集临床和实验室数据，在研究期间，对患者的并发症和住院情况进行了随访，并进行统计学分析。
■我们的大多数患者患有E-β地中海贫血（245，59.81％），其次是β-地中海贫血（102，28.30%）。NAAT确诊的HCV感染（14.21%）是最常见的感染，其次是HBV（2.51％），最后是HIV-1（0.58％）感染。在感染的地中海贫血患者中，平均HCVRNA为741063±438514.67IU/ml,而平均HBVDNA水平为4082863±7298514IU/ml.HIV-1和HCV以及HBV和HCV的共感染均在一名患者中被发现（0.28％）。HCV相关性肝病（14.21%）和生长迟缓（10.31%）是最典型的并发症，在研究期间，有5例患者（1.39%）死亡。
■初级保健医生应该知道HCV感染是印度东部农村地区地中海贫血患者中最常见的TTI。
■地中海贫血患者（n=359，年龄从1岁到60岁不等）在地中海贫血诊所就诊或为了更好的管理而进入室内设施被纳入研究。本研究仅包括经高效液相色谱（HPLC）诊断并具有经典临床特征的患者。根据NACO方案对这些患者的血液样本进行HIV测试。对于HBV和HCV，首先对样品进行血清学检测;收集反应性样品并将其在冷链中送往较高的核酸扩增检测中心(NAAT)进行定性和定量评估.收集临床和实验室数据，在研究期间，对患者的并发症和住院情况进行了随访，并进行统计学分析。
■我们的大多数患者患有E-β地中海贫血（245，59.81％），其次是β-地中海贫血（102，28.30%）。NAAT确诊的HCV感染（14.21%）是最常见的感染，其次是HBV（2.51％），最后是HIV-1（0.58％）感染。在感染的地中海贫血患者中，平均HCVRNA为741063±438514.67IU/ml,而平均HBVDNA水平为4082863±7298514IU/ml.HIV-1和HCV以及HBV和HCV的共感染均在一名患者中被发现（0.28％）。HCV相关性肝病（14.21%）和生长迟缓（10.31%）是最典型的并发症，在研究期间，有5例患者（1.39%）死亡。
■初级保健医生应该知道HCV感染是印度东部农村地区地中海贫血患者中最常见的TTI。
