PDF(Pubmed)
Abstract：
UNASSIGNED: Lichen planus is a chronic inflammatory disease of the skin and mucous membrane with higher predilection seen in the female population. Oral lichen planus (OLP) has been associated with various etiological factors, such as stress, hormonal imbalance, and immunological variation. The purpose of this study was to assess serum and salivary estrogen (E2) levels in OLP patients and correlate them with stress levels.
UNASSIGNED: This study aimed to evaluate serum and salivary estrogen levels in female patients with OLP, along with the assessment of stress and its correlation with estrogen levels.
UNASSIGNED: A total of 78 females, 39 clinically diagnosed with OLP and 39 healthy females, were included in the study as the case and control groups, respectively. 2 ml each of salivary and serum samples was obtained from each participant to measure the estrogen levels. Stress levels in the study group patients were assessed using the Depression Anxiety Stress Scale (DASS-21) and the Perceived Stress Scale (PSS). The nonparametric Mann-Whitney test was used for intergroup comparisons.
UNASSIGNED: Significantly higher serum estrogen levels with higher DASS-21 and PSS scores were noted in patients with OLP. Overall, significant positive correlations were observed between salivary E2 and serum E2 (r = 0.361, P = 0.001). There was a positive correlation between salivary and serum E2 and DASS score (r = 0.410, P < 0.001, and r = 0.768, P < 0.001, respectively), serum/salivary E2 and PSS score (r = 0.745, P < 0.001, and r = 0.410, P < 0.001, respectively), and DASS score and PSS score (r = 0.878, P < 0.001).
UNASSIGNED: Estrogen can be used as a useful biomarker for OLP in the future. Salivary samples can prove to be an accurate and feasible alternative to serum estrogen level determination. We also suggest that OLP patients must be given supportive psychological treatment for improved life quality and disease management.
UNASSIGNED: This study aimed to evaluate serum and salivary estrogen levels in female patients with OLP, along with the assessment of stress and its correlation with estrogen levels.
UNASSIGNED: A total of 78 females, 39 clinically diagnosed with OLP and 39 healthy females, were included in the study as the case and control groups, respectively. 2 ml each of salivary and serum samples was obtained from each participant to measure the estrogen levels. Stress levels in the study group patients were assessed using the Depression Anxiety Stress Scale (DASS-21) and the Perceived Stress Scale (PSS). The nonparametric Mann-Whitney test was used for intergroup comparisons.
UNASSIGNED: Significantly higher serum estrogen levels with higher DASS-21 and PSS scores were noted in patients with OLP. Overall, significant positive correlations were observed between salivary E2 and serum E2 (r = 0.361, P = 0.001). There was a positive correlation between salivary and serum E2 and DASS score (r = 0.410, P < 0.001, and r = 0.768, P < 0.001, respectively), serum/salivary E2 and PSS score (r = 0.745, P < 0.001, and r = 0.410, P < 0.001, respectively), and DASS score and PSS score (r = 0.878, P < 0.001).
UNASSIGNED: Estrogen can be used as a useful biomarker for OLP in the future. Salivary samples can prove to be an accurate and feasible alternative to serum estrogen level determination. We also suggest that OLP patients must be given supportive psychological treatment for improved life quality and disease management.
摘要：
■扁平苔藓是一种皮肤和粘膜的慢性炎症性疾病，在女性人群中表现出更高的好发性。口腔扁平苔藓（OLP）与各种病因相关，如压力，荷尔蒙失衡,和免疫学变异。这项研究的目的是评估OLP患者的血清和唾液雌激素（E2）水平，并将其与压力水平相关联。
■本研究旨在评估女性OLP患者的血清和唾液雌激素水平，以及压力的评估及其与雌激素水平的相关性。
■共有78位女性，39名临床诊断为OLP和39名健康女性，作为病例组和对照组纳入研究，分别。从每个参与者获得唾液和血清样品各2ml以测量雌激素水平。使用抑郁焦虑压力量表（DASS-21）和感知压力量表（PSS）评估研究组患者的压力水平。非参数Mann-Whitney检验用于组间比较。
■OLP患者血清雌激素水平明显升高，DASS-21和PSS评分较高。总的来说,唾液E2与血清E2呈显著正相关(r=0.361,P=0.001)。唾液与血清E2和DASS评分呈正相关(r=0.410,P<0.001,r=0.768,P<0.001),血清/唾液E2和PSS评分（分别为r=0.745，P<0.001，r=0.410，P<0.001），DASS评分和PSS评分(r=0.878,P<0.001)。
■雌激素将来可以用作OLP的有用生物标志物。唾液样本可以证明是血清雌激素水平测定的准确可行的替代方法。我们还建议OLP患者必须给予支持性心理治疗，以改善生活质量和疾病管理。
■本研究旨在评估女性OLP患者的血清和唾液雌激素水平，以及压力的评估及其与雌激素水平的相关性。
■共有78位女性，39名临床诊断为OLP和39名健康女性，作为病例组和对照组纳入研究，分别。从每个参与者获得唾液和血清样品各2ml以测量雌激素水平。使用抑郁焦虑压力量表（DASS-21）和感知压力量表（PSS）评估研究组患者的压力水平。非参数Mann-Whitney检验用于组间比较。
■OLP患者血清雌激素水平明显升高，DASS-21和PSS评分较高。总的来说,唾液E2与血清E2呈显著正相关(r=0.361,P=0.001)。唾液与血清E2和DASS评分呈正相关(r=0.410,P<0.001,r=0.768,P<0.001),血清/唾液E2和PSS评分（分别为r=0.745，P<0.001，r=0.410，P<0.001），DASS评分和PSS评分(r=0.878,P<0.001)。
■雌激素将来可以用作OLP的有用生物标志物。唾液样本可以证明是血清雌激素水平测定的准确可行的替代方法。我们还建议OLP患者必须给予支持性心理治疗，以改善生活质量和疾病管理。
