PDF(Pubmed)
Abstract：
Corona virus disease (COVID-19) initially appeared to be an exclusively respiratory ailment. While that is true in a vast majority of the cases, its evolution and later evidence have shown that it can afflict virtually any organ system in the human body after first gaining entry through the respiratory tract. The COVID-19 vaccines were one of the turning points in the campaign to control the COVID-19 pandemic. However, after their extensive use all over the world, it has emerged that they can cause some dangerous collateral damage. We, herein, report the case of a 58-year-old woman who presented to us with signs and symptoms of acute intestinal obstruction 4 months after receiving her first dose of Covishield® vaccination for COVID-19. Her blood tests showed a high D-dimer and normal platelet count. She was previously admitted to the hospital with an acute abdomen 3 months back. A contrast-enhanced computed tomography (CECT) scan of the abdomen done then had revealed thrombi in the aorta and inferior mesenteric and splenic arteries. She was started on low-molecular-weight heparin and discharged on tablet Warfarin after clinical improvement. CECT abdomen done during her present admission revealed a proximal small bowel stricture with dilated proximal and collapsed distal loops. She underwent a laparoscopic jejuno-ileal resection anastomosis. During the post-operative period, a repeat CECT abdomen done to evaluate multiple episodes of vomiting revealed pulmonary embolism in the lower chest cuts. A venous Doppler revealed extensive deep venous thrombosis of the left lower limb. A thrombophilia profile diagnosed anti-phospholipid antibody syndrome, an exacerbation of which was likely precipitated by the COVID-19 vaccine.
摘要：
冠状病毒病(COVID-19)最初似乎是一种纯粹的呼吸道疾病。虽然在绝大多数情况下都是如此，它的进化和后来的证据表明，在首次进入呼吸道后，它几乎可以影响人体的任何器官系统。COVID-19疫苗是控制COVID-19大流行运动的转折点之一。然而,在世界各地广泛使用后，已经发现它们可能会造成一些危险的附带损害。我们,在这里，报告一例58岁女性在接受第一剂Covishield®COVID-19疫苗接种后4个月出现急性肠梗阻的体征和症状。她的血液检查显示D-二聚体高，血小板计数正常。她之前3个月前因急腹症入院。然后对腹部进行了对比增强计算机断层扫描（CECT）扫描，发现主动脉，肠系膜下动脉和脾动脉有血栓。她开始使用低分子量肝素，并在临床改善后使用华法林片剂出院。在入院期间进行的CECT腹部检查显示近端小肠狭窄，近端扩张和远端环塌陷。她接受了腹腔镜空肠-回肠切除吻合术。术后期间,为评估多次呕吐而进行的重复CECT腹部检查显示，下胸部切口有肺栓塞。静脉多普勒显示左下肢广泛的深静脉血栓形成。血栓形成倾向诊断为抗磷脂抗体综合征，这种恶化可能是由COVID-19疫苗引起的。
