PDF(Pubmed)
Abstract：
UNASSIGNED: Studies on the effect of vaccine type and two other vaccines other than inactivated vaccines approved in China on in vitro fertilization (IVF) pregnancy outcomes are rare. To complement and confirm the existing findings, this research aimed to investigate whether there are adverse effects of different vaccine types in females and males on reproductive function and clinical pregnancy.
UNASSIGNED: This retrospective study enrolled 6,455 fresh embryo transfer cycles at the First Affiliated Hospital of Zhengzhou University between May 1, 2021, and October 31, 2022. The primary outcome is the clinical pregnancy rate (CPR). At the same time, the secondary results are the number of oocytes retrieved, two pronuclei (2PN) rate, blastocyst formation rate, high-quality blastocyst rate, and semen parameters (volume, density, sperm count, forward motility rate, total motility rate, immobility rate, and DNA fragment index (DFI) rate).
UNASSIGNED: In the comparison of ovarian stimulation indicators, no statistically significant differences (P > 0.05) were found in Gn days, endometrial thickness, 2PN rate, metaphase 2 (MII) rate, high-quality embryo rate, and blastocyst formation rate. No significant differences (P>0.05) were found in age, body mass index (BMI), education level, and semen parameters (volume, density, sperm count, forward motility rate, total motility rate, immobility rate, and DFI rate) in these four groups. The multivariate regression model showed that neither the types of vaccines nor the vaccination status of both infertile couples significantly affected clinical pregnancy.
UNASSIGNED: The type of vaccine does not appear to have an unfavorable effect on ovarian stimulation, embryo development, semen parameters, and clinical pregnancy.
UNASSIGNED: This retrospective study enrolled 6,455 fresh embryo transfer cycles at the First Affiliated Hospital of Zhengzhou University between May 1, 2021, and October 31, 2022. The primary outcome is the clinical pregnancy rate (CPR). At the same time, the secondary results are the number of oocytes retrieved, two pronuclei (2PN) rate, blastocyst formation rate, high-quality blastocyst rate, and semen parameters (volume, density, sperm count, forward motility rate, total motility rate, immobility rate, and DNA fragment index (DFI) rate).
UNASSIGNED: In the comparison of ovarian stimulation indicators, no statistically significant differences (P > 0.05) were found in Gn days, endometrial thickness, 2PN rate, metaphase 2 (MII) rate, high-quality embryo rate, and blastocyst formation rate. No significant differences (P>0.05) were found in age, body mass index (BMI), education level, and semen parameters (volume, density, sperm count, forward motility rate, total motility rate, immobility rate, and DFI rate) in these four groups. The multivariate regression model showed that neither the types of vaccines nor the vaccination status of both infertile couples significantly affected clinical pregnancy.
UNASSIGNED: The type of vaccine does not appear to have an unfavorable effect on ovarian stimulation, embryo development, semen parameters, and clinical pregnancy.
摘要：
■关于中国批准的除灭活疫苗外的疫苗类型和其他两种疫苗对体外受精（IVF）妊娠结局的影响的研究很少。为了补充和确认现有的发现，本研究旨在调查不同疫苗类型对女性和男性的生殖功能和临床妊娠是否有不利影响。
■这项回顾性研究于2021年5月1日至2022年10月31日在郑州大学第一附属医院进行了6,455个新鲜胚胎移植周期。主要结果是临床妊娠率（CPR）。同时,次要结果是检索到的卵母细胞数量，两个原核（2PN）率，囊胚形成率,高质量的囊胚率，和精液参数(体积，密度,精子计数,正向运动率，总运动率，不动率，和DNA片段指数(DFI)率)。
■在卵巢刺激指标的比较中，Gn天差异无统计学意义(P>0.05),子宫内膜厚度,2PN率，中期2（MII）率，优质胚胎率，和囊胚形成率。年龄差异无统计学意义(P>0.05),体重指数（BMI），教育水平,和精液参数(体积，密度,精子计数,正向运动率，总运动率，不动率，和DFI率)在这四组中。多元回归模型显示，疫苗的类型和两名不孕夫妇的疫苗接种状态均不会显着影响临床妊娠。
■疫苗的类型似乎对卵巢刺激没有不利影响，胚胎发育,精液参数,和临床妊娠。
■这项回顾性研究于2021年5月1日至2022年10月31日在郑州大学第一附属医院进行了6,455个新鲜胚胎移植周期。主要结果是临床妊娠率（CPR）。同时,次要结果是检索到的卵母细胞数量，两个原核（2PN）率，囊胚形成率,高质量的囊胚率，和精液参数(体积，密度,精子计数,正向运动率，总运动率，不动率，和DNA片段指数(DFI)率)。
■在卵巢刺激指标的比较中，Gn天差异无统计学意义(P>0.05),子宫内膜厚度,2PN率，中期2（MII）率，优质胚胎率，和囊胚形成率。年龄差异无统计学意义(P>0.05),体重指数（BMI），教育水平,和精液参数(体积，密度,精子计数,正向运动率，总运动率，不动率，和DFI率)在这四组中。多元回归模型显示，疫苗的类型和两名不孕夫妇的疫苗接种状态均不会显着影响临床妊娠。
■疫苗的类型似乎对卵巢刺激没有不利影响，胚胎发育,精液参数,和临床妊娠。
