PDF(Pubmed)
Abstract：
UNASSIGNED: Investigating the effects of electroacupuncture (EA) treatment on cardiovascular function and aortic lipid profiles in spontaneously hypertensive rats (SHR) constitutes the foundational focus of this study. The overarching goal is to comprehensively elucidate the alterations brought about by EA treatment and to assess its potential as an alternative therapy for hypertension.
UNASSIGNED: Consecutive EA treatments were administered to SHR, and the effects on systolic blood pressure, cardiac function, and hypertension-related neuronal signals were assessed. Aortic lipid profiles in vehicle-treated SHR and EA-treated SHR groups were analyzed using mass spectrometry-based lipid profiling. Additionally, the expression of Cers2 and GNPAT, enzymes involved in the synthesis of specific aortic lipids, was examined.
UNASSIGNED: The study demonstrated that consecutive EA treatments restored systolic blood pressure, improved cardiovascular function, and normalized hypertension-related neuronal signals in SHR. Analysis of the aortic lipid profiles revealed distinct differences between the vehicle-treated SHR group and the EA-treated SHR group. Specifically, EA treatment significantly altered the levels of aortic sphingomyelin and phospholipids, including very long-chain fatty acyl-ceramides and ether phosphatidylcholines. These changes in aortic lipid profiles correlated significantly with systolic blood pressure and cardiac function indicators. Furthermore, EA treatment significantly altered the expression of Cers2 and GNPAT.
UNASSIGNED: The findings suggest that EA may influence cardiovascular functions and aortic lipid profiles in SHR.
UNASSIGNED: Consecutive EA treatments were administered to SHR, and the effects on systolic blood pressure, cardiac function, and hypertension-related neuronal signals were assessed. Aortic lipid profiles in vehicle-treated SHR and EA-treated SHR groups were analyzed using mass spectrometry-based lipid profiling. Additionally, the expression of Cers2 and GNPAT, enzymes involved in the synthesis of specific aortic lipids, was examined.
UNASSIGNED: The study demonstrated that consecutive EA treatments restored systolic blood pressure, improved cardiovascular function, and normalized hypertension-related neuronal signals in SHR. Analysis of the aortic lipid profiles revealed distinct differences between the vehicle-treated SHR group and the EA-treated SHR group. Specifically, EA treatment significantly altered the levels of aortic sphingomyelin and phospholipids, including very long-chain fatty acyl-ceramides and ether phosphatidylcholines. These changes in aortic lipid profiles correlated significantly with systolic blood pressure and cardiac function indicators. Furthermore, EA treatment significantly altered the expression of Cers2 and GNPAT.
UNASSIGNED: The findings suggest that EA may influence cardiovascular functions and aortic lipid profiles in SHR.
摘要：
■研究电针（EA）治疗对自发性高血压大鼠（SHR）的心血管功能和主动脉脂质分布的影响是本研究的基础。总体目标是全面阐明EA治疗带来的变化，并评估其作为高血压替代疗法的潜力。
■对SHR连续进行EA治疗，以及对收缩压的影响，心功能,和评估高血压相关的神经元信号。使用基于质谱的脂质谱分析分析媒介物处理的SHR和EA处理的SHR组中的主动脉脂质概况。此外,Cers2和GNPAT的表达，参与特定主动脉脂质合成的酶，被检查过。
■研究表明，连续的EA治疗可以恢复收缩压，改善心血管功能，SHR中与高血压相关的神经元信号正常化。主动脉脂质概况的分析揭示了媒介物处理的SHR组和EA处理的SHR组之间的明显差异。具体来说,EA治疗显着改变了主动脉鞘磷脂和磷脂的水平，包括非常长链的脂酰神经酰胺和醚磷脂酰胆碱。主动脉脂质分布的这些变化与收缩压和心功能指标显着相关。此外，EA处理显著改变了Cers2和GNPAT的表达。
■研究结果表明，EA可能会影响SHR的心血管功能和主动脉脂质分布。
■对SHR连续进行EA治疗，以及对收缩压的影响，心功能,和评估高血压相关的神经元信号。使用基于质谱的脂质谱分析分析媒介物处理的SHR和EA处理的SHR组中的主动脉脂质概况。此外,Cers2和GNPAT的表达，参与特定主动脉脂质合成的酶，被检查过。
■研究表明，连续的EA治疗可以恢复收缩压，改善心血管功能，SHR中与高血压相关的神经元信号正常化。主动脉脂质概况的分析揭示了媒介物处理的SHR组和EA处理的SHR组之间的明显差异。具体来说,EA治疗显着改变了主动脉鞘磷脂和磷脂的水平，包括非常长链的脂酰神经酰胺和醚磷脂酰胆碱。主动脉脂质分布的这些变化与收缩压和心功能指标显着相关。此外，EA处理显著改变了Cers2和GNPAT的表达。
■研究结果表明，EA可能会影响SHR的心血管功能和主动脉脂质分布。
