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Abstract：
Delving into the immunological crossroads of liver diseases, this editorial explores the dynamic interplay between hepatitis C virus (HCV) and autoimmune hepatitis (AIH). While HCV primarily manifests as a viral infection impacting the liver, previous studies unveil a captivating connection between HCV and the emergence of AIH. The dance of the immune system in response to HCV appears to set the stage for an intriguing phenomenon-an aberrant autoimmune response leading to the onset of AIH. Evidence suggests a heightened presence of autoimmune markers in individuals with chronic HCV infection, hinting at a potential overlap between viral and autoimmune liver diseases. Navigating the intricate terrain of viral replication, immune response dynamics, and genetic predisposition, this editorial adds a layer of complexity to our understanding of the relationship between HCV and AIH. In this immunological crossroads, we aim to unearth insights into the complex interplay, using a compelling case where AIH and primary sclerosing cholangitis overlapped following HCV treatment with direct-acting antivirals as background.
摘要：
深入研究肝病的免疫学十字路口，这篇社论探讨了丙型肝炎病毒（HCV）和自身免疫性肝炎（AIH）之间的动态相互作用。虽然HCV主要表现为影响肝脏的病毒感染，先前的研究揭示了HCV与AIH的出现之间的迷人联系。免疫系统对HCV的反应似乎为一种有趣的现象-一种导致AIH发作的异常自身免疫反应奠定了基础。证据表明，在慢性HCV感染的个体中，自身免疫标志物的存在增加，提示病毒性和自身免疫性肝病之间的潜在重叠。在病毒复制的复杂地形上导航，免疫反应动力学，和遗传倾向，这篇社论为我们对HCV和AIH之间关系的理解增加了一层复杂性.在这个免疫学的十字路口，我们的目标是发掘复杂的相互作用的见解，使用一个令人信服的病例，其中AIH和原发性硬化性胆管炎在以直接作用抗病毒药物为背景的HCV治疗后重叠。
