PDF(Pubmed)
Abstract：
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.
摘要：
血液微量采样（BµS）提供了使用血浆或血清来分析人类健康的传统方法的替代方法，具有微创性和成本效益，特别有利于弱势群体。我们提出了一个非系统的综述，提供了分析方法的概要，2022年和2023年，干血微量采样在靶向和非靶向代谢组学和脂质组学研究中的应用和前景。BµS在新生儿和儿科研究中显示出潜力，治疗药物监测，代谢物筛选，生物标志物研究，体育监督,临床疾病研究和法医毒理学。值得注意的是,干血点和体积吸收微量采样选项比其他体积技术更广泛的研究。因此,我们建议,体积技术的进一步研究和应用将有助于使用BµS作为常规方法的替代方法.相反，我们支持这样的观点，即使用BµS时分析方法的协调将对其实施产生积极影响。
