PDF(Pubmed)
Abstract：
Detecting foodborne contamination is a critical challenge in ensuring food safety and preventing human suffering and economic losses. Contaminated food, comprising biological agents (e.g. bacteria, viruses and fungi) and chemicals (e.g. toxins, allergens, antibiotics and heavy metals), poses significant risks to public health. Microfluidic technology has emerged as a transformative solution, revolutionizing the detection of contaminants with precise and efficient methodologies. By manipulating minute volumes of fluid on miniaturized systems, microfluidics enables the creation of portable chips for biosensing applications. Advancements from early glass and silicon devices to modern polymers and cellulose-based chips have significantly enhanced microfluidic technology, offering adaptability, flexibility, cost-effectiveness and biocompatibility. Microfluidic systems integrate seamlessly with various biosensing reactions, facilitating nucleic acid amplification, target analyte recognition and accurate signal readouts. As research progresses, microfluidic technology is poised to play a pivotal role in addressing evolving challenges in the detection of foodborne contaminants. In this short review, we delve into various manufacturing materials for state-of-the-art microfluidic devices, including inorganics, elastomers, thermoplastics and paper. Additionally, we examine several applications where microfluidic technology offers unique advantages in the detection of food contaminants, including bacteria, viruses, fungi, allergens and more. This review underscores the significant advancement of microfluidic technology and its pivotal role in advancing the detection and mitigation of foodborne contaminants.
摘要：
检测食源性污染是确保食品安全和防止人类痛苦和经济损失的关键挑战。受污染的食物,包含生物制剂(例如细菌，病毒和真菌)和化学品(例如毒素，过敏原，抗生素和重金属)，对公众健康构成重大风险。微流体技术已经成为一种变革性的解决方案，用精确和有效的方法彻底改变污染物的检测。通过在小型化系统上操纵微小体积的流体，微流体可以创建用于生物传感应用的便携式芯片。从早期的玻璃和硅设备到现代聚合物和基于纤维素的芯片的进步显着增强了微流体技术，提供适应性，灵活性,成本效益和生物相容性。微流体系统与各种生物传感反应无缝集成，促进核酸扩增，目标分析物识别和准确的信号读出。随着研究的进展,微流体技术有望在解决食源性污染物检测中不断发展的挑战方面发挥关键作用。在这篇简短的评论中，我们深入研究各种制造材料，用于最先进的微流体设备，包括无机物,弹性体，热塑性塑料和纸张。此外,我们研究了几种应用，其中微流体技术在检测食品污染物方面具有独特的优势，包括细菌,病毒,真菌,过敏原和更多。这篇综述强调了微流控技术的重大进步及其在推进食源性污染物检测和缓解方面的关键作用。
