关键词: erectile dysfunction herbal medicines international index of erectile function penile erection traditional medicine

来  源:   DOI:10.3831/KPI.2024.27.2.82   PDF(Pubmed)

Abstract:
UNASSIGNED: Nitric oxide is the most important mediator of penile erection after the onset of sexual excitement. It activates cyclic guanosine monophosphate (cGMP), increasing penile blood flow. Most pharmaceutical medications prevent enzyme phosphodiesterase type 5 (PDE-5) from breaking down cGMP, thus keeping its level high. However, due to the adverse effects of pharmacological therapies, herbal drugs that improve sexual function have gained attention recently. This study aimed to investigate the combined effects of ginseng, Tribulus terrestris, and L-arginine amino acid on the sexual performance of individuals with erectile dysfunction (ED) using the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire.
UNASSIGNED: Over three months, 98 men with erectile dysfunction were randomly assigned to receive either 500 mg of herbal supplements or placebo pills. Each herbal tablet contained 100 mg of protodioscin, 35 mg of ginsenosides, and 250 mg of L-arginine.
UNASSIGNED: The results showed that the changes in the average scores of ILEF-5 within each group before and after the intervention indicated that all parameters related to the improvement of sexual function in patients with erectile dysfunction improved in the herbal treatment group (p < 0.001). The herbal group significantly improved IIEF-5 scores in non-diabetics (p < 0.05). However, there was no significant difference in the changes of IIEF-5 scores between the two intervention and control groups in diabetic patients.
UNASSIGNED: In conclusion, ginseng, Tribulus terrestris, and L-arginine have properties that increase energy and strengthen sexual function, making them suitable for patients with sexual disorders.
摘要:
一氧化氮是性兴奋发作后阴茎勃起的最重要介质。它激活环磷酸鸟苷(cGMP),增加阴茎血流量.大多数药物可以防止5型磷酸二酯酶(PDE-5)分解cGMP,从而保持其高水平。然而,由于药物治疗的不利影响,改善性功能的草药最近受到关注。本研究旨在探讨人参的联合作用,刺槐,使用国际勃起功能指数(IIEF-5)问卷的5项版本,以及L-精氨酸氨基酸对勃起功能障碍(ED)个体的性表现的影响。
三个月以上,98名患有勃起功能障碍的男性被随机分配接受500毫克草药补充剂或安慰剂。每片草药都含有100毫克的原药,35毫克人参皂苷,和250mgL-精氨酸。
结果表明,干预前后各组内ILEF-5平均得分的变化表明,与勃起功能障碍患者性功能改善有关的所有参数在中药治疗组中有所改善(p<0.001)。中药组显着改善非糖尿病患者的IIEF-5评分(p<0.05)。然而,在糖尿病患者中,两个干预组和对照组的IIEF-5评分变化无显著差异.
总而言之,人参,刺槐,和L-精氨酸具有增加能量和增强性功能的特性,使它们适合性障碍患者。
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