PDF(Pubmed)
Abstract：
UNASSIGNED: Cognitive impairments, ranging from mild to severe, adversely affect daily functioning, quality of life, and work capacity. Despite significant efforts in the past decade, more than 200 promising drug candidates have failed in clinical trials. Herbal remedies are gaining interest as potential treatments for dementia due to their long history and safety, making them valuable for drug development. This review aimed to examine the mechanisms behind the effect of Polygonum multiflorum on cognitive function.
UNASSIGNED: This study focused primarily on the effects of Polygonum multiflorum and its chemical constituents on cognitive behavioral outcomes including the Morris water maze, the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment and Alzheimer\'s disease (AD) like amyloid deposition, amyloid precursor protein, tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the mechanisms behind Polygonum multiflorum\'s impact on cognitive function was conducted. We reviewed the most recent data from preclinical research done on experimental models, particularly looking at Polygonum multiflorum\'s effects on cognitive decline and AD.
UNASSIGNED: According to recent research, Poligonum multiflorum and its bioactive components, stilbene, and emodin, influence cognitive behavioral results and regulate the pathological target of cognitive impairment and AD. Their mechanisms of action include reducing oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis, and promoting increased neurogenesis and synaptogenesis.
UNASSIGNED: This review serves as a comprehensive compilation of current experiments on AD and other cognitive impairment models related to the therapeutic effects of Polygonum multiflorum. We believe that these findings can serve as a basis for future clinical trials and have potential applications in the treatment of human neurological disorders.
UNASSIGNED: This study focused primarily on the effects of Polygonum multiflorum and its chemical constituents on cognitive behavioral outcomes including the Morris water maze, the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment and Alzheimer\'s disease (AD) like amyloid deposition, amyloid precursor protein, tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the mechanisms behind Polygonum multiflorum\'s impact on cognitive function was conducted. We reviewed the most recent data from preclinical research done on experimental models, particularly looking at Polygonum multiflorum\'s effects on cognitive decline and AD.
UNASSIGNED: According to recent research, Poligonum multiflorum and its bioactive components, stilbene, and emodin, influence cognitive behavioral results and regulate the pathological target of cognitive impairment and AD. Their mechanisms of action include reducing oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis, and promoting increased neurogenesis and synaptogenesis.
UNASSIGNED: This review serves as a comprehensive compilation of current experiments on AD and other cognitive impairment models related to the therapeutic effects of Polygonum multiflorum. We believe that these findings can serve as a basis for future clinical trials and have potential applications in the treatment of human neurological disorders.
摘要：
■认知障碍，从轻度到重度，对日常功能产生不利影响，生活质量,和工作能力。尽管在过去十年中做出了巨大的努力，200多种有希望的候选药物在临床试验中失败。由于其悠久的历史和安全性，草药作为痴呆症的潜在治疗方法正在引起人们的兴趣，使它们对药物开发有价值。本文旨在探讨何首乌对认知功能影响的机制。
■这项研究主要关注何首乌及其化学成分对认知行为结果的影响，包括莫里斯水迷宫，被动回避测试，还有Y迷宫,以及认知障碍和阿尔茨海默病（AD）的致病目标，如淀粉样蛋白沉积，淀粉样前体蛋白，tau过度磷酸化，和认知能力下降。此外,对何首乌影响认知功能的机制进行了全面评估。我们回顾了在实验模型上进行的临床前研究的最新数据，特别是观察何首乌对认知衰退和AD的影响。
■根据最近的研究，何首乌及其生物活性成分,二苯乙烯,还有大黄素,影响认知行为结果，调节认知功能障碍和AD的病理目标。它们的作用机制包括减少氧化和线粒体损伤，调节神经炎症，停止凋亡，促进神经发生和突触发生。
■这篇综述是关于AD和其他与何首乌治疗效果相关的认知障碍模型的当前实验的综合汇编。我们相信这些发现可以作为未来临床试验的基础，并在人类神经系统疾病的治疗中具有潜在的应用。
■这项研究主要关注何首乌及其化学成分对认知行为结果的影响，包括莫里斯水迷宫，被动回避测试，还有Y迷宫,以及认知障碍和阿尔茨海默病（AD）的致病目标，如淀粉样蛋白沉积，淀粉样前体蛋白，tau过度磷酸化，和认知能力下降。此外,对何首乌影响认知功能的机制进行了全面评估。我们回顾了在实验模型上进行的临床前研究的最新数据，特别是观察何首乌对认知衰退和AD的影响。
■根据最近的研究，何首乌及其生物活性成分,二苯乙烯,还有大黄素,影响认知行为结果，调节认知功能障碍和AD的病理目标。它们的作用机制包括减少氧化和线粒体损伤，调节神经炎症，停止凋亡，促进神经发生和突触发生。
■这篇综述是关于AD和其他与何首乌治疗效果相关的认知障碍模型的当前实验的综合汇编。我们相信这些发现可以作为未来临床试验的基础，并在人类神经系统疾病的治疗中具有潜在的应用。
