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Abstract：
UNASSIGNED: We aimed to explore changes in plasma and urine indole lactic acid (ILA) levels and the relationship between inflammation and ILA in chronic kidney disease (CKD) patients and healthy people.
UNASSIGNED: Forty-seven CKD patients and 30 healthy individuals were included in this study. One-way ANOVA was used for variables with normal distribution and homogeneous variance. A rank-sum test was performed for non-normally distributed variables. Correlation analyses were performed using Pearson\'s or Spearman correlation analyses. Independent relationship between patients and CKD was analyzed using ordinal and binary logistic regressions. Receiver operating characteristic (ROC) curve was used.
UNASSIGNED: Plasma and urine ILA levels were positively correlated (r = 0.51, P < 0.01). Plasma ILA was positively correlated with BMI, age, creatinine, BUN, triglycerides, and uric acid and negatively correlated with hemoglobin levels. Urine ILA levels were positively correlated with age, creatinine, BUN, and uric acid and negatively correlated with hemoglobin and albumin levels. Ordered logistic regression analysis showed that CKD was significantly correlated with plasma ILA (OR=4.49, P < 0.01), urinary ILA (OR=2.14,P < 0.01), urea levels (OR=1.43, P < 0.01) and hemoglobin levels (OR=0.95, P < 0.01) were significantly related. ROC curves indicated that plasma and urinary ILA were reliable predictors of CKD. CKD was correlated with plasma, urine ILA (OR=5.92, P < 0.01; OR=2.79, P < 0.01) and Hs-CRP (OR=2.45, P < 0.01).
UNASSIGNED: Plasma and urine ILA can potentially be used as biomarkers of CKD and inflammatory status.
UNASSIGNED: Forty-seven CKD patients and 30 healthy individuals were included in this study. One-way ANOVA was used for variables with normal distribution and homogeneous variance. A rank-sum test was performed for non-normally distributed variables. Correlation analyses were performed using Pearson\'s or Spearman correlation analyses. Independent relationship between patients and CKD was analyzed using ordinal and binary logistic regressions. Receiver operating characteristic (ROC) curve was used.
UNASSIGNED: Plasma and urine ILA levels were positively correlated (r = 0.51, P < 0.01). Plasma ILA was positively correlated with BMI, age, creatinine, BUN, triglycerides, and uric acid and negatively correlated with hemoglobin levels. Urine ILA levels were positively correlated with age, creatinine, BUN, and uric acid and negatively correlated with hemoglobin and albumin levels. Ordered logistic regression analysis showed that CKD was significantly correlated with plasma ILA (OR=4.49, P < 0.01), urinary ILA (OR=2.14,P < 0.01), urea levels (OR=1.43, P < 0.01) and hemoglobin levels (OR=0.95, P < 0.01) were significantly related. ROC curves indicated that plasma and urinary ILA were reliable predictors of CKD. CKD was correlated with plasma, urine ILA (OR=5.92, P < 0.01; OR=2.79, P < 0.01) and Hs-CRP (OR=2.45, P < 0.01).
UNASSIGNED: Plasma and urine ILA can potentially be used as biomarkers of CKD and inflammatory status.
摘要：
■我们旨在探讨慢性肾脏病（CKD）患者和健康人血浆和尿液吲哚乳酸（ILA）水平的变化以及炎症与ILA之间的关系。
■本研究包括47名CKD患者和30名健康个体。单向方差分析用于具有正态分布和齐次方差的变量。对非正态分布变量进行秩和检验。使用Pearson或Spearman相关性分析进行相关性分析。使用序数和二元逻辑回归分析患者与CKD之间的独立关系。采用受试者工作特征(ROC)曲线。
■血浆和尿液ILA水平呈正相关(r=0.51,P<0.01)。血浆ILA与BMI呈正相关,年龄,肌酐,BUN,甘油三酯，与血尿酸水平呈负相关。尿ILA水平与年龄呈正相关,肌酐,BUN,血尿酸水平与血红蛋白和白蛋白水平呈负相关。有序logistic回归分析显示CKD与血浆ILA显著相关(OR=4.49,P<0.01),尿ILA(OR=2.14,P<0.01),尿素水平(OR=1.43,P<0.01)与血红蛋白水平(OR=0.95,P<0.01)显著相关。ROC曲线表明血浆和尿ILA是CKD的可靠预测因子。CKD与血浆相关,尿ILA(OR=5.92,P<0.01;OR=2.79,P<0.01)和Hs-CRP(OR=2.45,P<0.01)。
■血浆和尿液ILA可能用作CKD和炎症状态的生物标志物。
■本研究包括47名CKD患者和30名健康个体。单向方差分析用于具有正态分布和齐次方差的变量。对非正态分布变量进行秩和检验。使用Pearson或Spearman相关性分析进行相关性分析。使用序数和二元逻辑回归分析患者与CKD之间的独立关系。采用受试者工作特征(ROC)曲线。
■血浆和尿液ILA水平呈正相关(r=0.51,P<0.01)。血浆ILA与BMI呈正相关,年龄,肌酐,BUN,甘油三酯，与血尿酸水平呈负相关。尿ILA水平与年龄呈正相关,肌酐,BUN,血尿酸水平与血红蛋白和白蛋白水平呈负相关。有序logistic回归分析显示CKD与血浆ILA显著相关(OR=4.49,P<0.01),尿ILA(OR=2.14,P<0.01),尿素水平(OR=1.43,P<0.01)与血红蛋白水平(OR=0.95,P<0.01)显著相关。ROC曲线表明血浆和尿ILA是CKD的可靠预测因子。CKD与血浆相关,尿ILA(OR=5.92,P<0.01;OR=2.79,P<0.01)和Hs-CRP(OR=2.45,P<0.01)。
■血浆和尿液ILA可能用作CKD和炎症状态的生物标志物。
